RESPIRATORY INFECTIONS Flashcards

1
Q

types of resp infections
- upper vs lower

A

upper- common cold, pharyn/laryngitis

lower- croup, bronchitis, pleuritis

RED = VIRAL

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1
Q

high surface area allows

A

lots of gas exchange across alveoli

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2
Q

Acute Bronchitis is

A

inflammation of tracheobronchial tree (bronchioles)

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3
Q

Bronchiolitis is

A

lung infection common in children and infants

  • swelling and irritation, build up of mucus in bronchioles
  • almost always caused by a virus
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4
Q

Pneumonia is

A

inflammation and consolidation of DEEP lung tissue
- alveoli filled with WBC and inflammatory debris

CAN EFFECT GAS EXCHANGE

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5
Q

How does gas exchange work

A

occurs across alveolar capillary membrane

  • maintain clear surface for high volume gas exchange and guard against systemic infection
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6
Q

risks (in the environment) for infection

A
  • loss of heat and moisture (ventilated pt)
  • allergens
  • aspiration of stomach content/oral secretions
  • particulate matter (breath in cough)
  • viruses, bacteria, fungi
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7
Q

how do we determine bacterial vs. fungal

A
  • clinical presentation/PE
  • diagnostic studies (galactomannan, crp biomarkers, CBC differential, chest imaging, culture sputum, PCR swab)
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8
Q

what is procalcitonin

A

precursor peptide from hormone calcitonin

released in response to bacterial toxins and pro inflamm mediators

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9
Q

in what type of infection is procalcitonin NOT released

A

viral infections do not promote PCT release

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10
Q

Common Cold- S+S and duration

A

self-limited
rhinorrhea, sore throat, cough, malaise, chills, headache, low grade fever or afebrile

duration: 9-10 days

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11
Q

Common Cold- etiology

A

viruses: rhinovirus, coronavirus, INFLUENZA VIRUS, RSV, adenovirus

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12
Q

Common cold- diagnosis

A

clinical diagnosis does usually not require diagnostics/tests

  • PCR nose swab, upper resp swab culture (strep), rapid strep, influenza, covid test
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13
Q

Common cold- treatment

A
  • antihistamines
  • anticholinergics
  • NSAID, ACETAMINOPHEN (pain management)
  • topical decongestants
  • cough suppressants
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14
Q

Influenza- S+S

A
  • abrupt onset fever and chills
  • sore throat
  • dry cough
  • CLEAR runny nose
  • myalgias, headaches
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15
Q

Influenza- diagnosis

A

PCR Nasopharyngeal swab
- can differentiate between subtypes of A

  • RAPID can only differentiate between type A and B
16
Q

Influenza- treatment

A

Oseltamivir/TAMIFLU (PO)

Zanamivir

Peramivir (IV)

Baloxavir Marboxil (PO)

17
Q

Influenza Neuraminidase Inhibitors
- different forms
- to what pts do you give

A
  • peramivir is IV
  • Inhaled and IV for people who cannot take oral medication
  • Oseltamivir to pts >2 weeks of age (only PO)
  • Zanamivir contraindicate with ASTHMA AND COPD (inhaled)
18
Q

RSV

A

presents as common cold in healthy adult

  • common cause of viral pneumonia
19
Q

RSV treatment

A

RIBAVIRIN- supportive care

Glucocorticoids and bronchodilators for bronchial reactivity

IVIG (IV immunoglobulin) if they are VERYYY ILL/unique situation

20
Q

RSV prevention

A

Palivizumab AND Nirsevimab (mABs)
- used in young children

NEW VAX FOR OLDER ADULTS/PREGO WOMEN*

21
Q

COVID transmission

A

RESPIRATORY DROPLETS- cough, sneeze, singing, talking, breathing

22
Q

Endothelitis- how does it occur

A

SARS-CoV-2 binds to host cells via ACE2 receptor in the epithelial cells

23
Q

Covid- symptoms

A

congestion, runny nose, loss taste/smell, headache, sore throat/cough, fatigue, muscle/body ache, shortness of breath, nausea/vom

24
Q

Covid- antigen test

A

rapid antigen test can be done, if negative repeat in 3-5 days

25
Q

Covid- treatments in order of preference

A

Nirmatrelvir + ritonavir (boosting agent) within 5 days symptom onset

Remdesivir within 7 days onset

DO not have to know alternative (molnupiravir)