Respiratory Flashcards
What is COPD?
A progressive obstructive lung disease, characterised by airflow limitations which are not fully reversible
What are histological changes you would find in COPD
Increased goblet cells
Enlargement of mucus secreting glands
What WBC are involved in COPD
macrophages but not eosinophils
A 70 year old male with an extensive smoking history presents to you. He has - productive cough - SOB on excessive - feeling tiered - Wheeze
What is his diagnosis?
COPD
What changes cause the increased resistance in the airways in COPD
decreased elasticity
fibrotic changes
luminal obstruction
What type of respiratory failure is characteristic in COPD
Type 2
What test is diagnostic for COPD and
What is the diagnostic cut off?
Spirometry, an FEV:FVC <0.7 post bronchodilator
What are possible consequences of COPD
pneumonia
pneumothorax
pulmonary hypertension
What investigation is most useful in a COPD exacerbation (excluding PFT). What may that show?
CXR may show hyperinflation (not linked to exacerbation) also pneumonia or pneumothorax.
Signs of:
Flattened diaphragm and increased retrosternal air space volume, indicating lung hyperinflation
Hyperlucency of the lungs
Rapid tapering of vascular markings
A patient has an FEV1 (% predicted) of >80 what is his GOLD grade
GOLD 1
A patient has an FEV1 (% predicted) of 50-70 what is his GOLD grade
GOLD 2
A patient has an FEV1 (% predicted) of 30-49 what is his GOLD grade
GOLD 3
A patient has an FEV1 (% predicted) of <30 what is his GOLD grade
GOLD 4
BREAK CARD - LOOK OVER ALL OF COPD QUICKLY
TAKE 5 MINUTES
A Patient has a mMRC=2+/ CAT >10 (mod-sev symptoms)and has had 0-1 exacerbations in the last year not requiring hospitalisation. What is his ABCD score (GOLD ABCD for COPD)
B
A Patient has a mMRC=0-1 / CAT <10 (mild-mod symptoms) and has had 2 + exacerbations in the last year or 1+ requiring hospitalisation. What is his ABCD score (GOLD ABCD for COPD)
C
A Patient has a mMRC=2+/ CAT >10 (mod-sev symptoms)and has had 2 + exacerbations in the last year or 1+ requiring hospitalisation. What is his ABCD score (GOLD ABCD for COPD)
D
How would you manage a patient in group A of (GOLD ABCD COPD)
SABA or LA Bronchodilator depending on effects of bronchodilator
How would you manage a patient in group B of (GOLD ABCD COPD)
LA Bronchodilator, if that is ineffective dual LA Bronchodilator therapy (SABA PRN)
How would you manage a patient in group C of (GOLD ABCD COPD)
Start on LA Bronchodilator, second line is dual LA Bronchodilator. If that is ineffective LABA + ICS (SABA PRN)
How would you manage a patient in group D of (GOLD ABCD COPD)
Start on dual LA Bronchodilator, if that is ineffective LABA + LAMA + ICS (triple therapy) and then LABA + ICS (SABA PRN)
What other therapies (not medical) are used regardless of GOLD ABCD in COPD
smoking cessation
Patient Vaccines
When would pulmonary rehabilitation be used in COPD
from group B-D
What is Theophalline (and aminophylline) and when would it be used in COPD
a xanthine, used to treat wheezing and SOB in chronic lung conditions.
In COPD it is an adjunct from group C-D
When would a phosphodiasterase 4 inhibitor be used in COPD, what does it do
group D and down regulates inflammation
when would a macrolide antibiotic be used in COPD, give two examples
in group D.
Examples would be Azithromycin or Clarithromycin
In what groups of COPD patients is O2 therapy indicated
group B - D
How would you investigate an exacerbation of COPD
FBC ECG CXR ABG Pulse Ox Sputum Cultures
How would you manage a COPD patient with exacerbation causing, fever, increase SOB, low O2 on air, and an increase in sputum (green colour) but no acidosis
Empirical antibiotics until more specific antibiotics can be used
What ventilation is indicated in COPD patients
NIV - BiPAP
Wha are the indications for ventilation in a COPD exacerbation
very low O2 sats
Respiratory acidosis
haemodynamic instability
What pathogens most commonly cause the common cold
rhinovirus (50%)
then: Coronavirus influenza parainfluenza RSV
A 5year old child presents to you with acute onset (1-2d) rhinitis, sore that, fever 38’c. On examination the back of his treat is red and inflamed
he is otherwise well
what is the diagnosis?
Common cold
What is the Fever Pain/ Centor criteria
criteria to determine if tonisitis is most likely bacterial
FeverPAIN criteria
Fever (during previous 24 hours)
Purulence (pus on tonsils)
Attend rapidly (within 3 days after onset of symptoms)
Severely Inflamed tonsils
No cough or coryza (inflammation of mucus membranes in the nose)
Centor criteria
Tonsillar exudate
Tender anterior cervical lymphadenopathy or lymphadenitis
History of fever (over 38°C)
Absence of cough
What pathogens commonly cause tonsillitis
rhinovirus
coronavirus
adenovirus
Group A streptococcus (B haemolytic)
What investigations might you like to carry out if you suspect bacterial tonsillitis
throat culture
rapid streptococcal antigen test
What is the management of viral tonsillitis
analgesia
What is the management of bacterial tonsillitis
analgesia
phenoxymethylpenicillin, 2ry Abx choice is azythromyocin
+/- dexamethasone if a patient has severe swelling
What is the criteria needed to get a tonsillectomy
7+ in one year
5+ in 2 years
3+ in 3 years
What is pharyngitis
can be difficult to distinguish from tonsilitis
is an acute onset of sore throat and pharyngeal inflammation
What pathogens can cause pharyngitis commonly
EBV, adenovirus, enterovirus
Group A strep, ghonnorhea, chlamydia
candida - immunocompromised
A 10 year old child presents to you.
They present to you with a very sore throat, on further examination you notice there is conjunctivitis and the beginning of a maculopapular rash.
You notice on their history that have not had Imms
What is the diagnosis? What sign would you find inspecting the mouth?
Measles
Koplick spots
Conjunctivitis and kopeck spots suggest easy stages of measles
A 14 year old child presents to you after having recently immigrated from India.
They have a high fever, barking cough, sore throat and lymphadenopathy. On inspection of the mouth you notice a grey adherent pseudomembrane.
What is the diagnosis?
Diptheria
What are the diagnostic investigations for diphtheria?
bacterial culture (throat) and microscopy
What is the treatment of Diptheria?
admit to hospital
diphtheria antitoxin
plus Benzylpenicillin sodium
Airway protection/intubation may be needed
Imms given
What do close contacts of someone diagnosed with dipheria require
erythromycin base
What is sinusitis?
symptomatic inflammation of the mucosal lining of the nasal cavity and paranasal sinuses. Usually symptoms last less than 4 weeks
What pathogens cause sinusitis?
Viral:
Rhinoviruses, influenza viruses, and parainfluenza viruses
Bacterial causes :
S. Pneumoniae and H Influenza
A patient presents to you with purulent nasal discharge, nasal congestion, facial pain and pressure by eyes/nose.
What is the diagnosis?
Viral sinusitis
A patient presented to you 5 days ago with what was thought to be viral sinusitis. They said that after their initial visit to you it has been getting worse.
What do you suspect? And what is the treatment?
its bacterial sinusitis
Amoxicillin/clavalanate
2ry option is clyndamycin
plus decongestants/iintranasal corticosteroids (mometasone) and ipatropium (anticholinergic) for rhinorrhea
What is the treatment for viral sinusitis
supportive therapy:
decongestants
intranasal corticosteroids (mometasone)
and ipatropium (anticholinergic) for rhinorrhea
what is asthma?
A chronic inflammatory airway disease with intermittent reversible airway obstruction and hyperactivity
A young patient comes in. They have been experiencing SOB, particularly worse in the morning and evening. They have noticed that cold air and exercise make symptoms worse and they develop a cough/
What is the most likely diagnosis?
Asthma
What kind of wheeze is associated with asthma ?
expiratory
What are risk factors for having asthma?
family history
eczema
Hayfece
(atopty)
what is FVC?
The force of air which can be forcibly and maximally expired out of the lungs after having filled the lungs with air. It is all of the air in the lungs apart from the residual volume.
What is FEV1?
The total amount of air which can be forcibly expired in one second after having maximally inspired.
what is the FVC/FEV1 ratio in asthma?
Should be less than 80% of the predicted value for the individual’s age height weight and ethnicity.
What is the first line diagnostic test in asthma?
Bronchodilator trial
What results would you expect to see in an asthmatic during a bronchodilator trial?
For the diagnosis of asthma there has to be a 12% improvement in FVC/FEV1 after bronchodilator therapy
how are lung functions measured?
Using spirometry
How is asthma monitored?
Peak expiratory flow rate
How would you classify the following symptoms of asthma:
symptoms less than twice a week
asymptomatic and normal peak expiratory flow rate between the attacks
attacks are brief with varying intensity
night-time symptoms occur less than twice a month
FEV1 or PEFR greater than 80% of predicted
PEFR variability is less than 20
Mild intermediate asthma
How you classify the following symptoms of asthma:
symptoms more than twice a week but usually less than once a day
when exacerbations are present they affect daily activities
the night-time symptoms more than twice a month
FEV1 is greater than 80% of predicted value
PEFR variability is between 20 and 30
Mild persistent asthma
How would you classify the following symptoms of asthma:
daily symptoms
use of SA BA daily
attacks affect daily activity
exacerbations are more than twice a week and may last for days
night-time symptoms present more than once a week
FEV1 is between 60 to 80% of predicted
PEFR variability is over 30
Moderate persistent asthma
How would you classify the following symptoms of asthma: continual symptoms Limited physical activity frequent exacerbations frequent nighttime symptoms FEV1 is less than 60% of predicted PEFR variability is over 60%
Severe persistent asthma
Describe a stepwise management of asthma
- SABA PRN
- ICS (low) (alternative cromolyn or montelukast)
- ICS (med)
- ICS (med) + LABA or Monetleukast
- ICS (high) + LABA or Monetleukast
- ICS (high) + LABA or Monetleukast + PO CS
What is the definition of an asthma exacerbation
An acute or subacute episode of progressive worsening symptoms and decreased baseline pulmonary function tests
What causes asthma exacerbations
Exposure to irritants
viral or bacterial infections
non-compliance to medication
How does an asthma exacerbation present
Presents with worsening of previous symptoms those are: cough wheeze chest tightness sleep disturbances signs of respiratory distress
What are some signs of respiratory distress
Use of accessory muscles tachyopnea tachycardia poor air movement diminished breath sounds
How would you investigate an exacerbation
do pulmonary function tests (peak flow is quick and safe)
measure O2 saturations
in severe exacerbations the following may be used
ABG
chest x-ray
+ cultures
A patient with an asthma exacerbation comes in with:
shortness of breath with activity
their PEF is over 70% of the predicted or personal-best
what is the severity of their exacerbation
Mild
A patient with an asthma exacerbation comes in with:
shortness of breath that interferes with usual activity
PEF is between 40 to 69% of predicted
what is the severity of their exacerbation
Moderate
A patient with an asthma exacerbation comes in with:
shortness of breath at rest
unable to complete a full sentence
pulmonary function tests are less than 40% of predicted
what is the severity of their exacerbation
Severe
A patient with an asthma exacerbation comes in with: severe shortness of breath possible reduction in consciousness too short of breath to speak perspiring PEF is less than 25% of the predicted
what is the severity of their exacerbation
Life threatening
How do manage a mild exacerbation (asthma)
Give 4-8 puffs of inhaled salbutamol every 20 minutes in four hours and then slowly decrease
you can give an adjunct per oral steroid- prednisolone for five days or until resolution
How do you manage a moderate to severe exacerbation?
Gives nebuliser salbutamol ideally nebulised with oxygen
give per oral steroids
give ipratropium bromide
give magnesium sulphate
if you suspect an impending respiratory failure data ICU and consider mechanical ventilation
if life-threatening cortical Hydro steroid IV can also be given
What is hypersensitivity pneumonitis?
Inflammation of the alveoli and distal bronchioles caused by an immune response to inhaled allergens
What are the causes of hypersensitivity pneumonitis
Bird droppings – bird fancier's lung compost lung farmers lung chemical workers lung lab work as lung
What are the three types of hypersensitivity pneumonitis?
Acute – occurring hours after exposure
subacute – developing weeks to months following exposure
chronic – developing months to years after exposure
What are the symptoms of hypersensitivity pneumonitis?
Flulike: shortness of breath non-productive cough (acute) or productive cough (sub acute or chronic) fever malaise weight loss especially in chronic
on examination you might find bibasilar rails, diffuse rails, clubbing.
A patient presents to you with progressively worsening shortness of breath, weight loss and productive cough.
They say they occasionally get fevers and that symptoms get worse
they also say that their work is of a farmer
what is the diagnosis?
Hypersensitivity pneumonitis
How would you investigate hypersensitivity pneumonitis
pulmonary function tests
Blood tests checking for immunological responses to causative antigen
chest x-ray or CT
full blood test (+WCC) ESR(+)
What might you find on a chest x-ray for hypersensitivity pneumonitis?
what about on CT?
X-rays show modular patchy infiltrates
CT shows ground glass shadowing central though bar nodules with relative basal sparing
What pattern would you see on the pulmonary function tests of hypersensitivity pneumonitis?
Acute tends to be restrictive
subacute and chronic have a mixed restrictive obstructive pattern
How do you treat hypersensitivity
pneumonitis?
Avoiding triggers
corticosteroids, prednisolone, either short-term if acute or subacute or long-term chronic
What is occupational asthma?
Asthma caused by workplace and may result from immunological or non-immunological stimuli
What are the two types of occupational asthma?
Sensitiser induced which is immunological
irritant induced which is non-immunological
Which type of occupational asthma has a latency period?
Sensitiser induced i.e. immunological
what is the typical causative agent of community-acquired pneumonia?
What are other causes?
Streptococcus pneumonias
haemophilus influenza
Staphylococcus aureus
group A Streptococcus
What are the causative agents of atypical pneumonia?
Mycoplasma pneumoniae
Legionella