Respiratory Flashcards
AAFB
Acid and Alcohol Fast Bacili
ABPA
Allergic Bronchopulmonary Aspergilosis
BIPAP
Bilevel Positive Airway Pressure
CPAP
Continuous Positive Airways Pressure
EAA
Extrinsic Allergic Alveolitis
ICD
Intercostal Chest Drain
ILD
Interstitial Lung Disease
INH
Inhaled
LTOT
Long Term Oxygen Therapy
MCL
Mid-Clavicular Line
NIV
Non-Invasive Ventilation
PEFR
Peak Expiratory Flow Rate
PFT’s
Pulmonary Function Tests
PND
Paroxysmal Nocturnal Dyspnoea
SVCO
Superior Vena Cava Obstruction
UIP
Usual Interstitial Pneumonia
Define vital capacity
Volume of air expired from the lungs from a maximal inspiration using a slow/relaxed manoeuvre
Define forced vital capacity
Volume of air than can be forcibly expelled from the lungs from a position of maximal inspiration
Define forced expiratory volume
Volume of air forcibly expelled from the lungs in the first second - following maximal inspiration
Define FEV1/FVC
Volume of air forcibly expired in the first second as a percentage of the total volume exhaled
Obstructive vs Restrictive spirometry
Obstructive - smooth curve reaching close to normal volume over a longer period of time
Restrictive - plateaus at a lower than normal volume
Early small airways obstruction on volume flow chart
Slight depression
Chronic obstructive diseases on volume flow chart
Large depression
Fixed large airway obstruction of volume flow chart
Circular
Restrictive disease on volume flow chart
Normal height but very narrow
Causes of low paO2
Hypoventilation
Diffusion impairment
Shunt
V/Q mismatch
Causes of respiratory acidosis
Hypoventilation
- neuromuscular diseases
Alveolar hypoventilation
- COPD
Define A-a gradient
A=alveolar
a= arterial
Difference between oxygen concentration in the alveoli and arterial system
How to calculate A-a gradient
PAO2 = PIO2 - PaCO2/0.8
PIO2 = room air (20kPa)
Normal A-a gradient
Young healthy people - less than 2kPa
Older people - less than 4kPa
> 4 = lung pathology
Define anaphylaxis/angioedema
Serious allergic reaction Occurs when sensitised individual exposed to specific antigen - insects bites/stings - food - medications
Pathophysiology of anaphylaxis
Immunological response
IgE -> Antigen -> mast cell and basophils -> histamine increases -> body response
Clinical features of anaphylaxis
Occurs in minutes
- pruritus, urticaria, angioedema, hoarseness
Progresses to
- stridor and bronchial obstruction, wheeze and chest tightness from bronchospasm
Treatment for anaphylaxis
Remove trigger, maintain airway - 100% O2
IM adrenaline 0.5 mg
IV hydrocortisone 200 mg
IV chlorpheniramine 10mg
If hypotensive - lie flat and fluid resuscitate
Bronchospasm - NEB salbutamol
Laryngeal oedema - NEB adrenaline
Features of mild asthma attack
No features of severe asthma
PEFR > 75%
Features of moderate asthma attack
No features of severe asthma
PEFR 50-75%
Features of severe asthma attack
PEFR 33-50% of best or predicted
Cannot complete sentences in 1 breath
RR > 25/min
HR > 110/min
Features of life-threatening asthma attack
PEFR < 33% of best or predicted
Sats < 92% or ABG pCO2 < 8kPa
Cyanosis, poor respiratory effort, near or fully silent chest
Exhaustion, confusion, hypotension or arrhythmias
Normal pCO2
Features of near fatal asthma attack
Raised pCO2
Acute asthma management
ABCDE
Aim for SpO2 94-98% with oxygen as needed - ABG if sats < 92%
5mg nebulised salbutamol - repeat after 15 mins
40mg oral Prednisolone STAT - IV hydrocortisone if PO not possible
If severe
- nebulised Ipratropium Bromide 500mg
- back to back salbutamol
If life threatening or near fatal
- urgent ITU or anaesthetist assessment
- urgent portable CXR
- IV aminophyline
- IV salbutamol if nebulised route ineffective
Features of COPD exacerbations
Infective - change in sputum volume / colour - fever - raised WCC +/- CRP Non-infective
Management of COPD exacerbations
ABCDE approach
Oxygen
- via fixed performance face mask due to risk of CO2 retention
- aim for SaO2 88-92% - guided by ABGs
NEBs - salbutamol and Ipratropium
Steroids - Prednisolone 30mg STAT and OD for 7 days
Antibiotics if raised CRP / WCC or purulent sputum
CXR
IV aminophylline
NIV if type 2 respiratory failure and pH 7.25-7.35
If pHh <7.25 consider ITU referral
Features of pneumonia
Consolidation on CXR with fever +/- purulent sputum +/- raised WCC and/or CRP
Management of pneumonia
ABCDE
If features of sepsis - immediately treat using sepsis pathway
Treat with antibiotics as per CURB-65 score
How to calculate CURB-65 score
1 point for Confusion Urea - > 7.0mmol/L RR > 30 BP < 90 mmHg Aged over 65
Definition of massive haemoptysis
> 240mls in 24 hrs
> 100mls/day over consecutive days
Management of massive haemoptysis
ABCDE
Lie patient on side of suspected lesion
Oral tranexamic acid for 5 days - or IV
Stop NSAIDs / aspirin / anticoagulants
Antibiotics if evidence of respiratory tract infection
Consider vitamin K
CT aortogram - bronchial artery embolisation
Features of tension pneumothorax
Hypotension
Tachycardia
Deviation of trachea away from side of pneumothorax - x-ray
Mediastinal shift away from pneumothorax
Management of tension pneumothorax
Large bore IV cannula into 2nd ICS MCL
Chest drain into affected side
Symptoms of PE
Chest pain - pleuritic
SOB
Haemoptysis
Low cardiac output followed by collapse
Risk factors for PE
Surgery - abdo/pelvic - knee/hip replacement - post-op ITU Lower limb - fracture - varicose veins Malignancy - abdo/pelvis/advanced/metastatic Reduced mobility Previous proven VTE
Management of PE
ABCDE Oxygen if hypoxia Fluid resuscitation - if hypotensive Thrombolysis considered if massive PE confirmed on echo or CT - check for contraindications Fully anticoagulated
Features of a massive PE
Hypotension/imminent cardiac arrest
Signs of right heart strain on CT/echo
Consider thrombolysis with IV alteplase
Thrombolysis contraindications
Absolute - haemorrhagic stroke or ischaemic stroke < 6 months - CNS neoplasia - recent trauma or surgery - GI bleed < 1 month - bleeding disorder - aortic dissection Relative - warfarin - pregnancy - advanced liver disease - infective endocarditis
Thrombolysis complications
Bleeding Hypotension Intracranial haemorrhage/stroke Reperfusion arrhythmias Systemic embolisation of thrombus Allergic reaction
Characteristics of asthma
Chronic inflammatory disease of the airways
Airway obstruction that is reversible - spontaneously or with treatment
Increased airway responsiveness to a variety of stimuli
Wheeze differentials
Acute asthma exacerbation
Bronchitis - viral or bacterial
Pulmonary oedema
PE
Asthma pathophysiology
Airway epithelial damage - shedding and sub epithelial fibrosis, basement membrane thickening
Cytokines amplify inflammatory response
Increased numbers of mucus secreting goblet cells and smooth muscle hyperplasia and hyper trophy
Mucus plugging - fatal and severe asthma
Inflammatory cells involved in asthma reactions
Eosinophils
Th2 lymphocytes
Mast cells
Inflammatory mediators released in asthma
Histamine
Leukotrienes
Prostaglandins