Gastro Flashcards
Basic advice for a healthy diet
BMI - 18.5-25
Base meals on starch - slower release carbohydrates
5 fruit and veg a day
Eat food high in fat, salt or sugar infrequently
Eat some meat, fish, eggs and beans - 2 portions of fish a week and reduce intake of red or processed meat
Eat some milk and dairy products
Moderate alcohol - less than 14 units over 3 or more days
Advice for taking supplements
Scant evidence for those able to follow a balanced diet
Women attempting to conceive - 400mcg/day folic acid from pre-conception to 12wks
Vitamin D (10mcg/day) for breast-feeding, over 65yrs old, dark skinand those not exposed to sun
Risks of too much sugar
Caries Diabetes Obesity - osteoarthritis - cancer - hypertension - increased oxidative stress
Best approach for weight loss
Motivational therapy
- referral to dietitian
- exercise and diet strategies
- targeted weight loss - psychotherapy
Treatment for obestiy
Primary prevention
Orlistat - lowers fat absorption
Surgery - potential for significant weight loss but also significant mortality
Define leucoplakia
Oral mucosal white patch that will not rub off and not attributable to other known disease
Premalignant lesion
Cause of oral hairy leucoplakia
Caused by EBV - seen in HIV
Define apthous ulcers
Shallow, painful ulcers on tongue or oral mucosa that heal without scarring
Causes of severe ulcers
Crohn's disease Coeliac disease Behcet's Trauma Erythema multiforme Lichen planus Pemphigus Pemphigoid Infections - herpes simplex, syphilis
Treatment of minor ulcers
Avoid oral trauma - hard toothbrush and foods
Avoid acidic foods and drinks
Tetracycline or antimicrobial mouthwashes (chlorhexidine)
Topical steroids - triamcinolone gel
Topical analgesia
Treatment of severe ulcers
Systemic corticosteriods - oral prednisolone 30-60mg/d PO for a week
Thalidomide - contraindicated in pregnancy
Biopsy if not healing after 3wks to exclude malignancy
Features of oral candidiasis
White patches or erythema of the buccal mucosa
Patches hard to remove and may bleed if scraped
Risk factors for oral candidiasis
Extremes of age
DM
Antibiotics
Immunosuppression - long-term corticosteriods (inhalers), cytotoxics, malignancy, HIV
Treatment for oral candidiasis
Nystatin suspension 400 000u (4ml swill and swallow/6hr)
Fluconazole - for oropharyngeal thrush
Define cheilitis
Angular stomatitis
Fissuring of the mouth’s corners
Causes of cheilitis
Denture problems
Candidiasis
Deficiency or iron or riboflavin (vitamin D)
Define gingivitis
Gum inflammation +- hypertrophy
Causes of gingivitis
Poor oral hygiene Drugs - pheytoin, ciclosporin, nifedipine Pregnancy Vitamin C deficiency Acute myeloid leukaemia Vincent's angina
Define microstomia
Mouth is too small
Causes of microstomia
Thickening and tightening of perioral skin after burns
Epidermolysis bullosa - destructive skin and mucous membrane blisters +- ankyloglossia
Systemic sclerosis
Causes of oral pigmentation
Peutz-Jehers’ - perioral brown spots
Addisons’ disease - pigmentation anywhere in mouth
Malignant melanoma
Telangiectasia - systemic sclerosis
Fordyce glands - creamy yellow spots at the border of the oral mucosa and lip vermilion
Sebaceous cysts
Aspergillus niger - black tongue
Sign of lead poisoning
Blue line at gum-tooth margin
Causes of yellow-brown discolouration of teeth
Prenatal or childhood tetracycline exposure
Causes of furred or dry tongue
Dehydration
Drug therapy
After radiotherapy
Crohn’s disease
Define glossitis
Smooth, red, sore tongue
Causes of glossitis
Iron, folate or B12 deficiency
Define macroglossia
Tongue is too big
Causes or macroglossia
Myxoedema
Acromegaly
Amyloid
Features of tongue cancer
Raised ulcer with firm edges
Risk factors of tongue cancer
Smoking
Alcohol
Pathway of spread of tongue cancer
Anterior 1/3 drains to submental node
Middle 1/3 to submandibular nodes
Posterior 1/3 to deep cervical nodes
Treatment for tongue cancer
Radiotherapy
Surgery
Causes of white intra-oral lesions
Idiopathic keratosis Leucoplakia Lichen planus Poor dental hygiene Candidiasis Squamous papilloma Carcinoma Hariy oral leucoplakia Lupus erythematosus Smoking Ahthous stomatitis Secondary syphilis
Indications for upper GI endoscopy
Diagnostic - haematemesis/malaena - dysphagia - dyspepsia - duodenal biopsy - persistent vomiting - iron deficiency Therapeutic - treatment of bleeding lesions - variceal banding and sclerotherapy - argon plasma coagulation for suspected vascular abnormality - stent insertion, laser therapy - stricture dilation, polyp resection
Pre-procedure for upper GI endoscopy
Stop PPIs 2wks prior
Nil by mouth 6 hrs before
Don’t drive for 24hrs if sedation used
Upper GI endoscopy procedure
Sedation optional - midazolam 1-5mg slowly IV
Nasal prong O2 - 2L/min + monitor sats
Spray pharynx with local anaesthetic
Continuous suction - prevent aspiration
Complications of upper GI endoscopy
Sore throat
Amnesia - sedation
Perforation
Bleeding - aspirin, clopidogrel, warfarin or DOACs stopped if therapeutic
Uses of duodenal biopsy
Gold standard for coeliac disease
Whipple’s disease
Giardiasis
Lymphoma
Uses of sigmoidoscopy
Views rectum + distal colon - to splenic flexure
Flexible has replaced rigid - 25% cancers still out of reach
Therapeutic - decompression of sigmoid volvulus
Sigmoidoscopy procedure
Do PR exam first
Biopsies
Indications of colonscopy
Diagnostic - rectal bleeding - iron-deficiency anaemia - persistent diarrhoea - positive faecal occult blood test - assessment or suspicion of IBD - colon cancer surveillance Therapeutic - haemostasis - clipping vessels - bleeding angiodysplasia lesion - colonic stent deployment - volvulus decompression - pseudo-obstruction - polypectomy
Colonoscopy preparation
Stop iron 1wk prior
Discuss bowl preparation and diet required
Colonoscopy procedure
Do PR first
Sedation and analgesia
Complications of colonoscopy
Abdominal discomfort
Incomplete examination
Haemorrhage after biopsy or polypecotmy
Perforation
Post-procedure of colonoscopy
No alcohol
No operating machinery for 24 hrs
Indications of video capsule endoscopy (VSE)
Evaluate obscure GI bleeding
Detect small bowel pathology
Pre-procedure for VSE
Small bowel imaging (contrast) or patency capsule test - if pt has abdo pain or symptoms suggesting obstruction
Clear fluids only evening before
Nill by mouth from morning till 4hr after capsule swallowed
VSE procedure
Capsule swallowed
Transmits wirelessly to capture devise worn by pt
Normal activities take place during day
Complications of VSE
Capsule retention - endoscopic or surgical removal
Obstruction
Incomplete exam - slow transit, achalasia
Problems with VSE
No therapeutic options
Poor localisation of lesions
May miss more subtle lesions
Routes for liver biopsy
Percutaneous - if INR in range
Transjugular - with FFP
Indications for liver biopsy
Increased LFTs of unknown origin
Assessment of fibrosis in chronic liver disease
Suspected cirrhosis
Suspected hepatic lesions/cancer