Respiratory Flashcards
What does it mean if the oxygen dissociation curve moves to the left?
It means Hb has a stronger association for O2, i.e. it binds it more strongly so Hb sat has gone up but O2 delivery to tissue goes down
What can shift the Oxygen Dissociation Curve to the left? (i.e. more associated)
Low [H+] (alkali)
Low pCO2
Low 2,3-DPG
Low temperature
The “L” rule
What can shift the Oxygen Dissociation Curve to the Right?
CADET:
CO2 Acid 2,3-DPG Exercise Temperature
Most common cause of bronchiolitis?
RSV - Resp Syncytial Virus
Wegener’s (GPA) and Goodpasture’s can both cause renal impairment and haemoptysis. How do they look different on renal biopsy?
Wegener’s - Crescentric Glomerulonephritis
Goodpasture’s – Linear IgG deposits in basement membrane
How do you get hypercalcaemia in sarcoid?
Macrophages increase conversion of Vit D to its active form (1,25-dihydroxycholecalciferol)
smooth non-tender fluctuant lump on side of neck?
What about on front?
Side = Branchial cyst
Front = Could be thyroglossal cyst
how is an alpha-1-antitrypsin deficiency inherited?
Autosomal Recessive