Respiratory Flashcards

1
Q

What does it mean if the oxygen dissociation curve moves to the left?

A

It means Hb has a stronger association for O2, i.e. it binds it more strongly so Hb sat has gone up but O2 delivery to tissue goes down

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2
Q

What can shift the Oxygen Dissociation Curve to the left? (i.e. more associated)

A

Low [H+] (alkali)
Low pCO2
Low 2,3-DPG
Low temperature

The “L” rule

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3
Q

What can shift the Oxygen Dissociation Curve to the Right?

A

CADET:

CO2
Acid
2,3-DPG
Exercise
Temperature
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4
Q

Most common cause of bronchiolitis?

A

RSV - Resp Syncytial Virus

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5
Q

Wegener’s (GPA) and Goodpasture’s can both cause renal impairment and haemoptysis. How do they look different on renal biopsy?

A

Wegener’s - Crescentric Glomerulonephritis

Goodpasture’s – Linear IgG deposits in basement membrane

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6
Q

How do you get hypercalcaemia in sarcoid?

A

Macrophages increase conversion of Vit D to its active form (1,25-dihydroxycholecalciferol)

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7
Q

smooth non-tender fluctuant lump on side of neck?

What about on front?

A

Side = Branchial cyst

Front = Could be thyroglossal cyst

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8
Q

how is an alpha-1-antitrypsin deficiency inherited?

A

Autosomal Recessive

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