Respiratory Flashcards

1
Q

Number drugs in development since completion of human genome project

Approvals

A

Up 62%

Down 25%- phase 2 failures

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2
Q

Amiloride

A

ENac blocker
Diuretic
Potassium sparing

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3
Q

Benefits of reverse pharmacology (3)

A

Historical success
Likely to find drug-like compounds
Insight into target biology

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4
Q

Drawback of reverse pharmacology

A

Will target be relevant to disease

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5
Q

FSK

A
Toxin
Activation of AC
Increase in cAMP
CFTR phosphorylation 
Channel opens
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6
Q

Genistein

A

Enhances CFTR activity has little effect on current at 37 but increases current at 26

Lower temperature seems to facilitate processing of F508

Still only 10% of WT

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7
Q

Frequency of F508

A

More than 90% patients have at least one copy

49% are homozygous

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