Lectures 7 & 8 Flashcards
Permeability
Ease by which ions pass through channel
Defined in terms of reference ion
A channel is selective for an ion when
It is more permeable to the ion of interest
All iGlus are permeant to
Monovalent cations
Na+, K+
Which iGlus are also permeable to divalent cation Ca2+
NMPARs
Some KARs
GluA2 lacking AMPARs
AMPAR conductance
Very fast
Rapid decay
NMDARs open
Slowly and close slowly
Potency is ___________ correlates with ________
Positively
Binding affinity
Rate of deactivation is __________ correlated with _________
Negatively
Potency
External Mg2+ is an
Open NMDAR channel blocker
Aka uncompetitive blocker
Mementine is a
Uncompetitive NMDAR blocker used to treat moderate to severe AD
Ketamine is a
Uncompetitive blocker of NMDAR
Two examples of non competitive antagonists of NMDAR
Zn2+
Ifenprodil
Non competitive AMPAR
Perampanel
Epilepsy treatment