Lectures 7 & 8 Flashcards

1
Q

Permeability

A

Ease by which ions pass through channel

Defined in terms of reference ion

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2
Q

A channel is selective for an ion when

A

It is more permeable to the ion of interest

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3
Q

All iGlus are permeant to

A

Monovalent cations

Na+, K+

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4
Q

Which iGlus are also permeable to divalent cation Ca2+

A

NMPARs
Some KARs
GluA2 lacking AMPARs

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5
Q

AMPAR conductance

A

Very fast

Rapid decay

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6
Q

NMDARs open

A

Slowly and close slowly

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7
Q

Potency is ___________ correlates with ________

A

Positively

Binding affinity

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8
Q

Rate of deactivation is __________ correlated with _________

A

Negatively

Potency

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9
Q

External Mg2+ is an

A

Open NMDAR channel blocker

Aka uncompetitive blocker

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10
Q

Mementine is a

A

Uncompetitive NMDAR blocker used to treat moderate to severe AD

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11
Q

Ketamine is a

A

Uncompetitive blocker of NMDAR

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12
Q

Two examples of non competitive antagonists of NMDAR

A

Zn2+

Ifenprodil

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13
Q

Non competitive AMPAR

A

Perampanel

Epilepsy treatment

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