Respiratory Flashcards
Stages of lung development
- Embryonic (3-7 wks)
- Pseudoglandular (5-17 wks)
- Canalicular (16-26 wks, surfactant secreting)
- Saccular (26-36 wks)
- Alveolar (36 wks to 3-8 yo)
Describe laryngomalacia
- Benign congenital extrathoracic airway disorder
- Underdeveloped cartilaginous support of supraglottic structures
Clinical presentation of laryngomalacia
Intermittent to persistent stridor in first 6 wks of life
Stridor caused by laryngomalacia worsens:
- In supine position
- Increased activity (crying)
- With URI
- During feedings
What contributes to the inspiratory obstruction in laryngomalacia?
Approximation of posterior edges of the epiglottis
Treatment and prognosis of laryngomalacia
- Improves with age
- Surgical epiglottoplasty if FTT, obstructive sleep apnea or resp insufficiency
When is surgical epiglottoplasty indicated in laryngomalacia?
- Failure to thrive
- Obstructive sleep apnea
- Resp insufficiency or severe dyspnea
Describe congenital vocal cord paralysis
- 15-20% of laryngeal anomalies
- Equal in both genders
- MC idiopathic etiology
Describe subglottic hemangiomas
- Congenital extrathoracic airway disorder
- Females 2:1
- Asymptomatic at birth w/progressive croup
How do subglottic hemangiomas present?
Asymptomatic at birth with progressive croup
Describe viral croup
- Parainfluenza
- Subglottic edema w/upper airway obstruction
- Croup (barking) cough
- Inspiratory stridor
- Fall and winter months
Clinical presentation of viral croup
- Afebrile or low grade fever
- Inspiratory stridor
- Barking cough (worse at night)
- Steeple sign on CXR
Treatment of viral croup
- Cool, moist air
- Racemic epi via nebulizer
- Dexamethasone
Clinical presentation of epiglottitis
- High fever, toxic appearance
- Drooling and dysphagia
- Muffled voice
- Inspiratory retractions
- Soft stridor
- Thumbprint sign on x-ray
Etiology of epiglottitis
- Hemophilus influenze type B (HIB)
- Now only in unimmunized children
Treatment of epiglottitis
- Immediate ET intubation
- Sedation for intubation/extubation is difficult to manage
- IV abx (ceftriaxone)
When is extubation performed in epiglottitis?
After visual inspection of epiglottitis (usually 24-48 hrs)
What is bacterial tracheitis?
- Pseudomembranous croup
- Severe, life threatening
- S. aureus MC
Clinical presentation of bacterial tracheitis
- Early symptoms are consistent with viral croup
- Subsequent increasing fever, toxicity, progressive airway obstruction
Treatment of bacterial tracheitis
- Debridement of airway w/intubation
- IV abx for H flu
- Longer intubation than for epiglottitis
Which requires longer intubation - epiglottitis or bacterial tracheitis?
Bacterial tracheitis
Cause of vocal cord paralysis?
Injury to phrenic nerve
- Difficult delivery
- Neck/thoracic surgery
- Trauma, mediastinal masses, CNS disease
Clinical presentation of vocal cord paralysis
- Hoarseness
- Aspiration
- High pitched stridor
What is the narrowest part of neonate or infant’s airway?
Subglottis
MC cause of subglottic stenosis
ET intubation
Treatment of subglottic stenosis
May require tracheostomy
Cause of laryngeal papillomatosis
HPV 6, 11, 16
Age of onset of laryngeal papillomatosis
Usually 2-4 yo
How to prevent laryngeal papillomatosis?
HPV vaccine
Treatment of laryngeal papillomatosis
- Direct surgical resection
- Spontaneous remissions do occur
Describe cartilage in infant airway
Softer, more pliable, can collapse easier
Describe tracheomalacia
- Cartilage in infant airway is softer and can collapse
- Cough, stridor, wheezing
What is diagnostic of tracheomalacia?
Tracheal collapse of more than 50% during inspiration
Congenital tracheomalacia may be a/w what?
Developmental abnormalities (tracheoesophageal fistula, vascular ring, etc.)
Treatment of tracheomalacia
May vary:
- Observation
- PPV (positive pressure ventilation)
- Surgery
How do vascular rings and slings present?
In infancy with stridor, wheeze, croupy cough
Where do bronchogenic cysts typically occur?
Middle mediastinum near carina and major bronchi
How are bronchogenic cysts developed?
Abnormal budding of primitive foregut
Treatment of bronchogenic cysts
Surgical resection with pulmonary PT
CXR finding of bronchogenic cyst
Filling of retrosternal clear space on lateral view
Describe foreign body aspiration
- Actual event RARELY seen
- Children 6 mo to 4 yo at highest risk
Clinical presentation of upper airway FB aspiration
Sudden onset cough and dysphonia
Clinical presentation of lower airway FB aspiration
Sudden onset cough, possible persistent cough or wheeze
Treatment of FB aspiration in the upper airway
- Allow spontaneous cough reflex first
- Otherwise, back blows per CPR
- NO finger sweeps