Respiratory Flashcards
1
Q
Tb management
Treatment of latent tb
A
6 months therapy via direct observed therapy (most effective to reduce resistance)
Stripe:
Streptomycin, rifampin, isoniazid, pyrazinamide, ethambutol
Latent tb treated with 9 month of isoniazid
Rifampin can’t be use alone as increase resistance now
Adverse effect:
Isoniazid: upregulate cyp2ei (enzyme that metabolise paracetamol to nadpqi, hepatotoxic), peripheral neuropathy - can’t be prevented with pyridoxine
Rifampin: hepatic clearance of other drugs, red compound in urine and tears
Ethambutol: optic neuritis
2
Q
Tb prevention
A
Isoniazid 300 mg oral for 6 months
