Antiplatelet

Question 1

Clopidogrel

• example
• moa
• SE
• monitor

Answer 1

Moa - irreversible binds to p2y12 adp receptor on platelet which block activation of glycoprotein iib/iiia pathway

SE- thrombocytopenia, bleeding. GI bleed aplastic anaemia, GI ulcers, allergy,

Indication - acs (loading dose of 300 mg follow by 75 mg daily)

Question 2

What does dipyridamole?

Answer 2

Inhibits platelets phosphodiesterase -> camp

Also use in cardiac stress

Question 3

Other example of glycoprotein Iib and iia pathway inhibitor

Answer 3

Abciximab

Tirofiban

Question 4

Aspirin

• example
• moa
• SE
• cautions

Answer 4

Moa: non selective NSAIDs that non compeitively blocks cox which inhibit synthesis of prostaglandins

Anti platelet via decrease synthesis of thromboxane a2 (platelet aggregation) via inhibition of cox

SE: gi bleed, bleed, hepatic injury and renal impairment, dyspepsia, cat c

Stop 7 days before surgery unless stent or cabg

Monitor: rf, UEC, GIT bleed
Indicated as first line for mi - 300 to 900 mg (every 4-6 hours) then 150 mg daily