Respiratory

Question 1

Causes of false positive sweat test

Answer 1

Adrenal insufficiency
Hypothyroidism and hypoparathyroidism
Glycogen storage
MPS
G6PD deficiency
Diabetes insipidus
Klinefelters
Renal failure

Question 2

Causes of false negative sweat test

Answer 2

Malnutrition
Skin oedema
Mineralocorticoid use

Question 3

CF
Thick brown sputum

Answer 3

Aspergillus

Question 4

CF
Diagnosis of pancreatic insufficiency with faecal elastase

Answer 4

Faecal elastase >200microg/L

Question 5

Common first presentation CF

Answer 5

Meconium ileus

Question 6

CF
Diagnostic chloride in sweat test

Answer 6

> /= 60mmol/L

Question 7

CF
Diagnostic chloride in sweat test

Answer 7

> /= 60mmol/L

Question 8

Right shifted curve = affinity for oxygen

Answer 8

Decreased

Question 9

Left shifted curve = affinity for oxygen

Answer 9

Increased

Question 10

Causes of right shift of oxygen-haemaglobin dissociation curve (decreased oxygen affinity, more oxygen delivery to tissues)

Answer 10

Low pH (more acidic)
Increased CO2
High temperature
High 2,3-DPG
Low O2 affinity Hb variants

Question 11

Causes of left shift of oxygen-haemaglobin dissociation curve (higher oxygen affinity, less oxygen delivery to tissues)

Answer 11

High pH
Low temperature
Low 2,3-DPG
Fetal Hb (HbF)
Methaemaglobinaemia
High O2 affinity Hb variants