Respiratory Flashcards
Allergic Rhinitis: What is it?
*Inflammation of nasal mucosa
*Causes histamine release
*Characterized by sneezing, watery eyes, and nasal congestion
*Caused by exposure to antigen (allergen)
antihistamine drug names
end in -ine
Diphenhydramine
*Antihistamine
*MOA: Histamine (H1) receptor blocker (first-generation)
*Adverse effects: drowsiness, or paradoxical CNS stimulation and excitability, anticholinergic effects, tachycardia, mild hypotension, maybe photosensitivity
Fexofenadine
*Antihistamine
*MOA: (H1) receptor blocker (2nd generation)
how to treat acute attacks
AIM
A: ALBUTEROL 1st
I: Ipratropium 2nd
M: Methylprednisolone 3rd
Intranasal corticosteroids
*steroids end in -sone
*drug of choice
*High efficacy and wide margin of safety
*Must be administered 2–3 weeks prior to allergen exposure
*Reduce swelling directly in resp. system
*slow onset (NOT A RESCUE DRUG)
*used 3rd in line
intranasal corticosteroid drug names
end in -one, -ide or -ium
fluticasone
*Intranasal corticosteroid.
*MOA: decreases inflammation in nasal passages
*Adverse: nasal irritation, epistaxis
Oxymetazoline
*MOA: Decongestant/ vasoconstrictor (NOT A STEROID - it’s a nasal spray)
*Adverse effects: rebound congestion when oxymetazoline is used for 3–5 days +
*Adverse: Minor stinging and dryness in nasal mucosa
Pseudoephedrine
- oral adrenergics
*Stimulates alpha- and beta-adrenergic receptors.
*Produces vasoconstriction in the respiratory tract mucosa (alpha-adrenergic stimulation) and possibly bronchodilation (beta2 -adrenergic stimulation).
Antitussives
inhibit cough
Opioids
*used to inhibit severe cough
*raise the cough threshold decreasing the frequency and intensity of the cough
*Hydrocodone and codeine
*Risk of dependency
Tessalon pearls
*antitussive
*“benzonatate”
*local anesthetic
dextromethorphan
*non-opiate antitussive
*MOA: acts in medulla to inhibit cough reflex
*Adverse effects: dizziness, drowsiness, GI upset
Expectorant
inhibit mucous production & loosens mucous