Respiratory Flashcards
How do you grade dyspnoea
- MRC Dyspnoea Scale
- Grade 1 – Breathless on strenuous exercise
- Grade 2 – Breathless on walking up hill
- Grade 3 – Breathless that slows walking on the flat
- Grade 4 – Stop to catch their breath after walking 100 meters on the flat
- Grade 5 – Unable to leave the house due to breathlessness
spirometry findings in COPD
- FEV1 /FVC ratio is <0.7
how is severity of airflow obstruction graded
- Stage 1: FEV1 >80% of predicted
- Stage 2: FEV1 50-79% of predicted
- Stage 3: FEV1 30-49% of predicted
- Stage 4: <30% of predicted
COPD investigations
- CXR
- To exclude other pathology like lung cancer
- FBC
- For polycythaemia which is a response to chronic hypoxia
- BMI
- As a baseline to assess weight loss (cancer or severe COPD) or weight gain (due to steroid therapy)
- Sputum culture
- To assess for chronic infections like pseudomonas
- Serum alpha-1 antitrypsin
- Alpha-1 antitrypsin deficiency leads to early onset and more severe COPD
- Transfer factor for carbon monoxide
- TLCO is decreased in COPD and can give an indication of severity of disease
Long term COPD management
- Smoking cessation
- Annual pneumococcal and flu vaccines
- Pulmonary rehab
- Stage 1
- SABA (e.g. salbutamol) or SAMA (e.g. ipratropium) to use as needed
- Stage 2
- LABA (e.g. formoterol, salmeterol) plus LAMA (e.g. tiotropium)
- Stage 3
- LABA plus LAMA plus ICS
- If no improvement in 3 months then switch back to LABA plus LAMA
management of acute exacerbation of COPD
- Nebulised bronchodilators (salbutamol and ipratropium)
- Steroids (hydrocortisone or oral prednisolone)
- Antibiotics if evidence of infection
- Physiotherapy
- If not responding to first line treatment
- IV aminophylline
- Non-invasive ventilation
- Intubation and ventilation with admission to intensive care
- Doxapram
investigation of asthma in the community
fractional exhaled nitric oxide
spirometry with bronchodilator reversibility
how would you define good asthma control
No daytime symptoms.
No night-time waking due to asthma.
No need for rescue medication.
No asthma attacks.
No limitations on activity including exercise.
Normal lung function (FEV1 and/or PEF > 80% predicted or best).
Minimal side-effects from medication.
additional management of asthma in the community
yearly asthma review
emergency plan
yearly flu jab
describe asthma treatment ladder in adults
- everyone gets a SABA
- SABA + low dose ICS (beclametasone)
- SABA + low dose ICS + LTRA (montelukast)
- SABA + low dose ICS + LABA (salmeterol) +/- LTRA (depending on response to LTRA)
- MART (maintenance and reliever therapy) +/- LTRA
- MART includes fast acting LABA and low dose ICS
- used as daily maintenance and as a reliever
- Switch to a MART with moderate dose ICS +/- LTRA
- consider additional drug such as theophylline or switching to high dose ICS
asthma treatment ladder in children
- SABA
- SABA + low dose ICS (beclametasone)
- SABA + low dose ICS + LTRA (montelukast)
- SABA + low dose ICS + LABA (salmetarol)
- SABA + MART (low dose ICS in the MART)
- SABA + moderate dose ICS + LABA (either as MART or fixed dose regimen)
- here you can either increase to high dose ICS or trial new drug such as theophylline
how can you establish whether someone’s asthma is well controlled
- answering no to all three of the RCP Three Questions is consistent with well controlled asthma
- are you having trouble sleeping because of your asthma symptoms?
- have you recently had your asthma symptoms during the day?
- has your asthma interfered with your normal activities?
how do you grade asthma attacks
- Mild: PEFR >75%
- Moderate: PEFR <75%
- Severe:
- PEFR <50%
- can’t complete sentences
- RR >25
- PR >110
- Life threatening (33 92 CHEST)
- 33: PEFR <33%
- 92: Sats <92%
- Cyanosis
- Hypotension
- Exhaustion
- Silent chest
- Tachycardia
management for moderate asthma attack
Nebulised beta-2 agonists (i.e. salbutamol 5mg repeated as often as required)
Nebulised ipratropium bromide
Steroids. Oral prednisolone or IV hydrocortisone. These are continued for 5 days
Antibiotics if there is convincing evidence of bacterial infection
management of severe asthma attack
management of life threatening asthma attack
IV magnesium sulphate infusion
admission to HDU/ICU
Intubation - however this should happen early as it’s very difficult to intubate in bronchospasm
ABGs in an asthma attack
Initially patients will have a respiratory alkalosis as tachypnoea causes a drop in CO2.
A normal pCO2 or hypoxia is a concerning sign as it means they are tiring and indicates life threatening asthma.
A respiratory acidosis due to high CO2 is a very bad sign in asthma.
what are the different types of lung cancer and how common are they
list sub-types in order of prevalence
- Non small cell lung cancer (80%)
- adenocarcenoma
- squamous cell carcinoma
- large cell carcinoma
- other
- small cell lung cancer (20%)
*
signs and symptoms of lung cancer
finger clubbing
coughing
haemoptysis
lymphadenopathy
recurrent pneumonia
weightloss
cough
investigations of lung cancer
- chest x ray
- contrast enhanced CT
- bronchoscopy
- biopsy (by bronchoscopy or percutaneously) and histological diagnosis
is prognosis generally better for small cell lung cancer or non-small cell lung cancer
non-small cell lung cancer generally has a better prognosis
treatment options for lung cancer
- surgery
- lobectomy
- segmentectomy
- wedge resection
- radiotherapy
- chemotherapy
- curative
- palliative
- treatment for small cell lung cancer
- outcomes usually worse so normally just radiotherapy and chemo
- palliative
- endobronchial treatment with stents and debulking works for palliative treatment of obstruction caused by cancer
list 9 extra pulmonary manifestations of lung cancer
what is recurrent laryngeal nerve palsy
presents as hoarse voice and is caused by lung cancer pressing on the recurrent laryngeal nerve
