Respiration Flashcards
located in the lipid interior of the membrane, ferries electrons from Complex I to Complex III, which contains cytochrome b
Ubiquinone/coenzyme Q (CoQ)
plays a critical role in both catabolic and anabolic processes and represents a major “hub” of metabolic activities in the cell
citric acid cycle
can undergo glycolysis once they have been converted to glucose 6-phosphate or fructose 6-phosphate
Carbohydrates other than glucose, including glycogen, starch, various disaccharides, and a number of monosaccharides
a peripheral membrane protein on the intermembrane-space side that shuttles back and forth between Complexes III and IV
cytochrome c
non-heme iron proteins that are additional components of the electron transport chain
iron-sulfur proteins
(exergonic) various pathways by which different organic molecules are broken down to yield energy
catabolism
is a key intermediate in cellular energy metabolism because it can be utilized in one of several pathways
Pyruvate
Electrons Removed from the Glucose Molecule Are Transferred to Oxygen
a series of electron carriers, each of which holds the electrons at a slightly lower energy level than the previous carrier
electron transport chain
phase that requires an energy investment of 2 ATP per glucose molecule. This stage ends with the splitting of the six-carbon sugar molecule into two three-carbon molecules.
Preparatory Phase
– was originally known as the Krebs cycle in honor of Sir Hans Krebs, whose research group was largely responsible for its elucidation; Krebs cycle is more commonly called the citric acid cycle or the TCA (tricarboxylic acid) cycle today, because it begins with the formation of citric acid, or citrate, which has three carboxylic acid (—COO-) groups
citric acid cycle
central to the biosynthetic processes of life
pyruvate or the acetyl group of acetyl CoA
which receives two electrons from NADH and passes them to CoQ
flavin mononucleotide (FMN)
Oxidizes the Acetyl Groups of the Acetyl CoA Molecules
citric acid cycle
depends on a gradient of protons (H+ ions) across the mitochondrial membrane and the subsequent use of the free energy stored in that gradient to form ATP from ADP and phosphate
Oxidative Phosphorylation
serve as an intermediate between two-electron carriers and one-electron carriers
ubiquinone, also called coenzyme Q (CoQ)
represent the cell’s net energy harvest from glycolysis
ATP & NADH
phase that produces an energy yield of 4 ATP and 2 NADH—a substantial return on the original investment. The net ATP yield is therefore 2 molecules of ATP per molecule of glucose.
payoff phase
drives the formation of ATP from ADP and Pi by oxidative phosphorylation
proton gradient
two distinct events take place in chemiosmotic coupling:
(1) a proton gradient is established across the inner membrane of the mitochondrion, and
(2) potential energy stored in the gradient is used to generate ATP from ADP and phosphate
the complete oxidation of sugars or other organic molecules to carbon dioxide and water
Respiration
the combination of the acetyl group and CoA and is the form in which carbon atoms from glucose enter the citric acid cycle
acetyl CoA
the overall reaction for the complete oxidation of glucose
C6H12O6 + 6O2 ⎯→ 6CO2 + 6H2O + Energy
— a large molecule consisting of a nucleotide linked to pantothenic acid, one of the B-complex vitamins
— often written as CoA-SH to indicate its sulfur group, where bonding occurs
coenzyme A (CoA)
electron acceptor; the first component of the electron transport chain
flavin mononucleotide (FMN)
can move freely within the lipid bilayer of the membrane and thus can shuttle electrons between other, less mobile carriers.
ubiquinone, also called coenzyme Q (CoQ)