resp pharmocology Flashcards
where are cell bodies of the preganglionic fibres located
brainstem
where are cell bodies of postganglionic fibres located
embedded in the walls of bronchi and bronchioles
stimulation of postganglionic cholinergic fibres causes
bronchial smooth muscle contraction
increased mucous secretion
stimulation of postganglionic non cholinergic fibres causes
bronchial smooth muscle relaxation
contraction of smooth muscle is the result of what
phosphorylation of myosin
relaxation of smooth muscle results from what
dephosphorylation of myosin by myosin phosphatase
In the presence of intracellular calcium ions, the rate of phosphorylation ___ the rate of dephosphorylation
exceeds
signs of asthma
hyperplasia + hypertrophy
accumulation of interstitial fluid (oedema)
increased secretion of mucous
epithelial damage exposing sensory nerve endings
sub - epithelial fibrosis
response in mild-moderate asthma
TH2
response in severe asthma
TH1
what do cross links IgE receptors stimulate
calcium entry into mast cells
release of calcium ions from intracellular stores
what does the release of calcium ions from intracellular stores evoke
release of secretary granules containing preformed histamine + the production and release of leukotrienes that cause smooth airway contraction
what do relievers act as
bronchodilators
what do controllers/preventers act as
anti-inflammatory agents
should long acting B adrenoceptor agonists be used alone
NO
