Resp Pharm

Question 1

omalizumab: mechanism, use

Answer 1

monoclonal anti-IgE antibody, allergic asthma resistant to inhales steroids and LABAs (not first-line)

Question 2

three main classes of bronchodilators

Answer 2

beta2-agonists, methylxanthines (theophylline), anticholinergic agents

Question 3

inhaled beta2 agonists: name them, mechanism

Answer 3

albuterol (short-acting), salmeterol (long-acting); relaxation of bronchial smooth muscle

Question 4

theophylline: mechanism, use

Answer 4

1. inhibit phosphodiesterase –> increase cAMP
2. blocks bronchoconstrictive effects of adenosine
   used in developing countries for asthma because it is cheap

Question 5

anticholinergic used to treat asthma

Answer 5

ipratropium

Question 6

ipratropium: mechanism, use

Answer 6

1. relaxes airway smooth muscle
2. decreases mucus secretions
   use: more effective in COPD than beta2 agonists

Question 7

beclomethasone: what is it, mechanism, use

Answer 7

inhaled corticosteroid; inhibits synthesis of cytokine, inactivates NFKB; first-line therapy for chronic asthma