Resp Dx Flashcards
What is the adult dosage for salbutamol
2.5mg x2
What is the paediatric dosage for salbutamol
1.25mg x 2
What is the adult dosage of Ipratropium bromide?
2.5mg x2
What is the paediatric dosage of Ipratropium bromide?
1.25mg- 2.5mg
What is the adult dosage for adrenaline in relation to respiration issues?
500 mcg
What is the dosage for adrenaline in re,action to respiratory issues in ages 6-11 years
300 mcg
What is the dosage for adrenaline in relation to respiratory issues in ages from birth-5 years
150 mcg
What is the mechanism of action of Salbutamol?
It is a Beta 2 adrenergic agonist which causes bronchodilation.
How does Salbutamol cause bronchodilation?
Promotes production of intercellular cyclic adenosine monophosphate which enhances the binding of intercellular calcium to the cell membrane.
This decreases calcium concentration within cells and= relaxation of smooth muscle and bronchodilation.
What is the mechanism of action of Ipratropium bromide?
It is an acetylcholine antagonist via the blockade of muscarinic cholinergic receptors, such as M2 receptors= decreasing the production of cyclic guanosine monophosphate = decreased contraction of smooth muscles.
Overall, when the receptors are blocked, increased release of acetylcholine and an increased bronchoconstriction response to cholinergic nerve stimulation.
What is the role of M2 receptors?
Identified at the terminals of cholinergic nerve endings and function as feedback regulators.
What is the role of M3 receptors?
Expressed in the trachea and bronchi cause vagally induced airway smooth muscle contraction and mucus secretion.
What is the role of M1 receptors?
When acetylcholine is released in the lungs, its acts in M1 receptors in postganglionic nerves that innervate the submucosal glands and airway smooth muscle= increases acteylcholine release by facilitating neurotransmission.
What is the role of acetylcholine in the respiratory system?
Contracts airway smooth muscle to control tone and regulate latency of the conducting airways.
