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YEAR 1 > resp drugs > Flashcards

resp drugs Flashcards

1
Q

SABA EX

A

salbutamol

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2
Q

SABA IN

A

asthma
COPD

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3
Q

SABA MA

A

B2 adrenoreceptor agonists

(bronchodilation + decrease in mucus)

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4
Q

SABA CC

A

arrhythmias
CVD
diabetes
HTN
hyperthyroidism
hypokalaemia
QT prolongation

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5
Q

SABA SA

A

tremor
can affect heart rhythm

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6
Q

LABA EX

A

beclomethasone

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7
Q

LABA IN

A

nocturnal asthma
COPD

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8
Q

LABA MA

A

B2 adrenoreceptor agonist - delayed onset

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9
Q

LABA CC

A

arrhythmias
CVD
diabetes
HTN
hyperthyroidism
hypokalaemia
QT prolongation

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10
Q

LABA SA

A

B2 down regulation + tachyphylaxis (tolerance) in long-term use

can worsen asthma when used alone

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11
Q

ICS IN

A

asthma
COPD

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12
Q

ICS MA

A

synthetic glucocorticoids, switches on genes

(anti-inflammatory, no bronchodilator effect)

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13
Q

ICS SA

A

dysphonia + oropharyngeal candidiasis

pneumonia in COPD

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14
Q

montelukast IN

A

+ in asthma

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15
Q

montelukast MA

A

cysteinyl leukotriene receptor antagonist

prevent CysLTs from causing bronchoconstriction, decrease mucus secretion + oedema

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16
Q

montelukast SA

A

generally well tolerated!
headache
GI upset

17
Q

theophylline IN

A

+ in asthma
(IV = acute)

18
Q

theophylline MA

A

xanthine

(maybe) inhibit phosphodiesterases -> inactivate cAMP + cGMP

(inhibit mast cells, increase mucus clearance, increase diaphragm contraction, decrease fatigue)

19
Q

theophylline CC

A

interactions w/ CYP450s (specific antibiotics)

20
Q

theophylline SA

A

v narrow therapeutic window!
supra = dysrhythmias, seizures, hypotension

therapeutic = N+V, headache, abdominal discomfort

21
Q

chromones IN

A

+ in severe allergic asthma

22
Q

chromones MA

A

mast cell stabilizer

23
Q

omalizumab IN

A

+ in asthma

24
Q

omalizumab MA

A

anti IgE

25
Q

mepolizumab / benralizumab IN

A

+ in asthma

26
Q

mepolizumab / benralizumab MA

A

anti IL-5 (eosinophilic)

27
Q

dupilumab IN

A

+ in asthma

28
Q

dupilumab MA

A

anti IL-4

29
Q

SAMA EX

A

ipratropium

30
Q

SAMA IN

A

acute COPD

31
Q

SAMA MA

A

non-selective m3 antagonist

stops bronchoconstriction, decrease mucus secretion

32
Q

LAMA EX

A

tiotropium

33
Q

LAMA IN

A

COPD

34
Q

LAMA MA

A

M3 antagonist - delayed onset

YEAR 1 (11 decks)

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