Resp Flashcards

1
Q
A

Gottrons papules

Characteristic discrete red areas overlying the knuckles in a patient with dermatomyositis. They may be photosensitive and itchy.

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2
Q
A

heliotrope rash (dermatomyositis)

Usually purplish colour. It may also be red in certain patients. This is commonly seen around the eyes, but may also be encountered on the upper chest or back.

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3
Q

Crepetations in dermatomyositis ?

A

Fine
- Pulm fibrosis

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4
Q

First line treatment for dermatomyositis

A

Steroids

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5
Q

Name 5 symptoms / signs of dematomyositis other than ones given away by the name

A

Skin rash
Muscle weakness

Muscle tenderness;
Weight loss;
Arthralgia;
Arthritis;
Dyspnea;
Arrhythmia;
Dysphagia;
Dysphonia;
Malignancy (in people >60);
GI ulcers and infections in children;
Tiptoe gait (children);
Joint contractures;
Subcutaneous calcifications

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6
Q

Diagnostic test for dematomyositis

A

Anti-mi-2
(only found in 30%)

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7
Q

Treatment of dematomyositis

A

Conservative
- avoiding sun exposure
- physio / nutrition to help reduce atrophy

Medical
Steroids
azathioprine / cyclosporin if not responding
Topical steroids;
Immunomodulatory medications;
Methotrexate;

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8
Q

COPD exam

A

Hands
- tar staining
- clubbed
- tremor eg salbutamol
- “ can you put hand out to stop traffic” Hand flap

Face

JVP

Trachea

Lympadenopathy

Chest inspection
- front, back and axilla for scar (pneumonectomy)

Chest expansion

Palpate - Heave

Precuss

Auscultate - POLYPHONIC wheeze

Ankle oedema

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9
Q

COPD presentation

A

Ive examined this 55 year old gentleman with tar staining and a degree of cachxia.

On exam there is a polyphonic wheeze and some hyper-expansion of the chest

They likely have a lung disease such as COPD or asthma

There was no evidence of pulm hypertension as evidenced by lack of JVP, lour second heart stone or peripheral oedema.

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10
Q

Differentials of polyphonic wheeze

A

COPD

Asthma

Eosinophilic granulomatosis

Rheum -> bronchiolitis obliterans

A1AT deficiency

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11
Q

Investigations in COPD

A

Bloods including ABG
FBC looking for anaemia / polycythemia and eosinophils
Consder vasculitis screen
IgE to aspergilous
Specific antigens in asthma

Sputum culutres

CXR

Consider Lung function tests
with reversibility testing
- Low TLco

Spirometry with peak flow measurements at morning and night to assess for diurnal variation

Consider echo if evidence of pulm HTN

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12
Q

What are you looking for on CT of COPD

A

Emphysema - hallmark

Bulous lung disease -> need for surgical treatments

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13
Q

What are you looking for on lung function tests of COPD

A

Non reversiblity with salbutamol

Obstructive pattern
FEV1/FVC ratio 0.7
<30, 30-50,50-70

FEV less than 80% predicted
- <15% improvement with bronchodilators

Low TLco

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14
Q

How are you going to manage COPD acute

A

Salbutamol / ipatropium nebs
Prednisolone
ABG - PCO2 / Bicarb
-> Consider NIV if not responding after an hour of treatment

Controlled oxygen therapy

FBC / CRP - consider abx
CXR - Consider abx

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15
Q

How are you going to manage COPD chronic

A

Conservative
-Stop smoking
- Pulmonary rehabilitation
- Flu / pneumococcal vaccines
- Dietician input
- LTOT

Medical
inhalers
- If no eosinophils / no reversibility
LABA / LAMA
- If some asthmatic features
-> ICS / LABA

Surgical
- Bullectomy (>1L and compressing surrounding lung)
- Lung reduction surgery if heterogenous distribution
- Single lung transplant

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16
Q

Criteria for LTOT

A

ABGs with PO2 <7.3

Or Po2 <8 with evidence of cor pulmonale
Stop smoking

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17
Q

Surgical management of COPD

A

Lung reduction management of areas with lots of deadspace / bullae
-> Allows rest of lung to re expand

Lung transplant -> more usually in A1AT

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18
Q

Bronchiectasis exam? What from end of bed might be a giveaway?

A

End of bed
- Young
- Sputum pots
- Nebuliser especially if nebulised Abx

Ask patient to cough - big wet productive cough and stable - high risk bronchiectasis

Hands
- Clubbing
- Evidence of autoimmune / crest features
- Yellow nail syndrome

Face
- little to see

Neck
- JVP - unlikely raised

Chest
- Inspect front and back - Eg scars
- Palpation heart - deviated apex and loud p2
- Percussion
- Auscultate - wet coarse crackles at base/s
->Must ask the patient to cough and re-auscultate and see if change (likely to shift secretions in bronchiectasis)
- Small amount of wheeze may be present

Legs
- Pedal oedema if RHF

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19
Q

Bronchiectasis presentation

A

Signs
Complications
Current evidence of treatment

I examined this patient who had coarse wet crepitation’s which were altered by coughing.

There was no evidence of Right heart failure as evidenced by normal JVP absence of loud P2, displaced apex and absence of peripheral oedema

There was evidence of ongoing treatment with nebulised antibiotics and inhalers.

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20
Q

Mainstay of bronchiectasis management

A

Antibiotics

NOT steroids

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21
Q

Range of DDs for bronchiectasis

A

Young
-Kartagner’s syndrome - bronchiectasis and dextrocardia
-Cystic fibrosis

Post infectious
-TB
- Childhood pneumonia / whooping cough

Autoimmune
-Lupus
- Sjorgrens
- Allergic bronchopulmonary aspergillus

Pulm fibrosis
- Shrunken scar lung -> pulls airways open

Aspiration
- Usually RLL and alcoholic / GORD

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22
Q

Bronchiectasis investigate

A

Bloods
- FBC and CRP markers of infection
- Autoimmune screen, ANA / immunoglobulins
- Consider IgE to aspergilus and Eosinophils

Sputum culture

CT scan - ideally HRCT

Lung function test

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23
Q

What makes an airway bronchiectatic on CT

A

If the airway is bigger than the adjacent blood vessel

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24
Q

Cystic fibrosis test

A

Chloride sweat test

Ciliary biopsy (from nose)

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25
Q

Bronchiectasis management

A

Conservative
- Chest physio
- Nutritional support
-Stop smoking
- Covid / flu / pneumococcus vaccines

Medical
- Treat triggers Eg autoimmune cause
-Carbocystine
- OPAT devices - which help get phlegm off chest
-Targeted antibiotic therapy from regular sputum samples
- often nebulised abx

Surgical
- Lobectomy if localised eg post TB
- Lug transplant if recurrent infections and declining FEV1 in CF

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26
Q

When would you put someone on prophylaxtic abx for bronchiectasis? Choice?

A

> 2 course of targeted Abx in 1 year

Azithromycin (or cipro)
Or nebulised antibiotics - colistin / gent / tobramycin

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27
Q

bugs in bronchiectasis?

A

Not too bad
-Haemophylis
- Strep pneumo

Med
-Klebsiella
-Staph

Worse
-pseudomonas

Worst
-Burkholderia

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28
Q

Resp exam with scars

A

Inspect surroundings

Observe breathing with patient exposed. Are they breathless
Ask patient to exhale fully then inhale fully
Look at position of trachea and Trails sign check for asymmetry of mastoid muscles

Hands
- Clubbing
- Tobacco staining
- Flap
- Pulse

Face
- Anaemia
- Horners (apical pancoast tumour)
- JVP
- Check for lymphnodes
- Scars at the back
- ->sacral oedma
- scars at axilla

Palpation
- Chest expansion Must start at end of expiration and involve full inspiration and expiration. Also start near bottom of sterum and complete higher close to axilla
- Apex beat and RV heave
- Precussion - dont forget apex and axilla

Ausculation
- If crepetations -> ask to cough then repeat

Complete vocal tactile phremitus and whispering pectoriloquy.
Temperature, sats and HR
Inspect sputum pot

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29
Q

What is trail sign

A

Excessive prominence of the clavicular head of the sternomastoid muscle on the side to which the trachea has shifted

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30
Q

Most common resp ddx for clubbing

A

Bronchiectasis
Cancer
Fibrosis

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31
Q

Lobeectomy / pnemonectomy exam

A

General inspection
Asymmetry of chest wall movement
Scars
Respiratory distress
Supplemental oxygen

Hands
Clubbing (bronchiectasis / malignancy / pulmonary fibrosis)
Tar staining (underlying malignancy)
Wasting of dorsal interossei (underlying malignancy)
Pulse: bounding +/- CO2 retention flap (COPD)

Face
Conjunctival pallor (anaemia of chronic disease)
Horner’s syndrome (underlying Pancoast tumour)
Central cyanosis

Neck
JVP (complication of pulmonary hypertension)
Cervical lymphadenopathy (underlying malignancy)
Tracheal deviation – usually deviated in upper lobectomy / pneumonectomy, towards the side of the surgery. May be central in lower lobectomy.

Chest
Inspect
Scars: lateral thoracotomy, VATS, chest drain
Ribs: pulled on over affected area
Palpate

Chest expansion:
Lobectomy: reduced anteriorly OR posteriorly
Pneumonectomy: completely reduced anteriorly AND posteriorly

Apex beat (displaced towards side of lobectomy / pneumonectomy)
Right ventricular heave (pulmonary hypertension complicating COPD / bronchiectasis)

Percuss: dull over area of lobectomy / pneumonectomy

Auscultate
Reduced breath sounds over lobectomy site
Normal breath sounds over normal lung
Absent breath sounds over whole hemithorax in pneumonectomy
May sound bronchial if overlying deviated trachea

Vocal resonance reduced over affected area
Listen for underlying aetiology:
Coarse crepitations in bronchiectasis
Prolonged expiratory phase / wheeze in COPD
Sacral oedema / pedal oedema for right heart failure

Complete examination by:
- Looking at vitals chart, specifically temperature and SpO2
- Obtain a chest radiograph
- Inspect sputum mug

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32
Q

Resp exam with this means?

A

Lung transplant

clamshell throacotomy

33
Q
A

Likely VATS scars

Chest drain

Could be just local excision eg skin Ca

34
Q

With lobectomy scar why might you hear normal breathsounds + no tracheal deviation

A

The remaining lung has expanded to gap

35
Q

Differentials for lobe ectomy
pneumonectomy

A

Lobe
- Most commonly Lung Ca
- Localized bronchiectasis
- Uncontrolled haemoptysis (e.g. following failed bronchial artery embolisation) from bronchiectasis / tuberculosis / underlying pneumonia
-Early non-small cell lung cancer
- Lung volume reduction surgery for COPD
- Lung abscess
- Trauma
- Solitary pulmonary nodule of unknown cause

  • Cystic fibrosis
  • ILD
36
Q

What would determine whether a patient could go for a lobeectomy / pneumonectomy in lung cancer

A

Staging of disease
CT / PET scan
- Staging EBUS (US scan during bronchoscopy)

Lung function tests
- 2L for pneumonectomy
- 1.5L for lobectomy

Others inclde
CPET - cardiopulmonary exercise testing (looking for vo2 max of 15mls/kg)
[Often on bike with mask for measuring gas exchange + ECG and sats probe]

37
Q

Complications of lung surgery

A

I would let the patient know about questions to ask thier surgeon.

Immediate post op
- Bleeding
- Mucous plugging

Intermediate
- Infection

Recovery time
Rehab options
Respiratory failure

38
Q
A

Posteriolateral thoracotomy

39
Q
A

Anteriolateral thoracotomy

40
Q

Single side thoracotomy means…

A

lobectomy
pneumonectomy
open lung biopsy
lung volume reduction or bullectomy
Single lung transplants

41
Q

Pulmonary fibrosis signs on exam

A

Inspection
- Cushingoid from steroids

Hands
- Clubbing
- Rheumatoid hands
- Sclerodactyly - CREST
- Irregular pulse - amiodarone

Chest
- Fine end expiratory crackles which do not move with coughing

Possible evidence of RHF

Sclerodactlyly - skin on the fingers or toes to thicken, tighten, and harden, resulting in a claw-like appearance

42
Q

Investigations for pulm fibrosis (not acute admission)

A

Bloods
- ESR, Rheum factor, ANA
-ABG - type 1 resp failure

CXR
Reticulonodular changes
Loss of definition of heart border

Lung funciton tests
- Restricictive (FEV1:FVC >0.8)
- Reduced lung capacity
- Recuded TLco (transfer factor for carbon monoxide) and KCO (diffusion coefficient)

HRCT
- Location of fibrosis helps with differentials

Consider biopsy

43
Q

Management of pulmonary fibrosis

A

Conservative
Patient education
Support groups
STOP smoking

Inflammatory
- Steroids
- Nintedanib

Idioipathic
- Pirfenidone
- Ninedanib

Surgical
- Single lung transplant

44
Q

Fine crackles over 1 lung and normal breath sounds on other with a scar?

A

Single lung transplant pulmonary fibrosis

45
Q
A
46
Q

Dermatomes
T4
T10
L5
S1

A

T4 - nipple
T10 - Umbilicus (belly butTEN)
L5 - Big toe (Largest of 5)
S1 - Little toe (Smallest 1)

47
Q

Causes of upper lung fibrosis

A

BREASTS

Berylliosis
Radiation
Extrinsic alergic alveolitis / eosinophilic pneumonia
Ankylosing spond / allergic bronchopulmonary aspergillosis
Sarcoid
TB
Silicossis

48
Q

Lower lung fibrosis causes

A

CABRIOS

Collagen vascular disease / cryptogenic fibrosis alveolitis
Asbestosis
Bronchiectasis
Rheum arthritis
Idiopathic
Other… (Blah never mind BNM) Bleomycin Nitrofurantoin MTX
Scleroderma

49
Q

Drugs which cause liver enzyme inhibition? What does this mean?

A

[Sick more drugs]
- Increased effect of drug

SICKFACES.COM
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol & Grapefruit juice
Chloramphenicol
Erythromycin
Sulfonamides
Ciprofloxacin
Omeprazole
Metronidazole

50
Q

Liver enzyme induction

A

Crap less drugs

CRAP GPs
Carbamazepine
Rifampicin
Alcohol
Phenytoin
Griseofulvin
Phenobarbitone
Sulphonylureas

51
Q

Rule of 10s for phaeo

A

10%
-Familial
-malignant
-outside adrenals
-Bilateral

52
Q

Which organisms in asplenia

A

His Spleen Never Got Sick

Haemophilus influenzae type B
Streptococcus pneumoniae
Neisseria meningitides
Group B streptococcus
Salmonella typhi

53
Q

Council patient about TB drugs and things to look out for.

A

Isoniazid
- Peripheral neuropathy (give pyridoxine to prevent)
- hepatitis

Rifampicin
- Increased metabolism of drugs eg COCP
- Orange secretions
- Hepatitis

Ethambutol
- Optic neuritis

Pyrazinamide - Hepatitis

If the whites of your eyes look yellow - stop taking your tablets and contact TB nurse

If red becomes less bright - contact TB nurse that day

New tingling in toes. Continue tablets and tell doctor at clinic visit

Secretions
- may permanently stain contacts -> should not be worn

If on contraceptive - should use barrier protection

54
Q

CXR of apical lobectomy will show

A

Likely just raised hemidiaphragm on that side

55
Q

Pleural effusion signs on exam? Signs to indicate cause?

A

Inspect
- Asymmetry of chest expansion if large
- Trachea deviated Away from effusion
- If ca and tethered lung with small effuson trachea may deviate towards

Precuss - Stony dull
- Reduced tactile vocal fremitus
- Reduced breath sounds

Cancer - clubbing , lymphadenopathy, mastectomy (Breast Ca V V V common cause of effusion

CCF
CLD
CKD
Connective tissue - Rheum hands, butterfly rash SLE

56
Q

What are the differentials for a unilateral dull lung base with reduced AE
name all 4.

A

Pleural effusion

Collapse

Pleural thickening - Esp if VATs scars etc

Raised hemidiaphragm
Eg lobectomy / Hepatomegaly / hepatic abscess

57
Q

Causes of transudative / exudative pleural effusion?
What on aspirate would make you think exudative? empyema?

A

Trans
- CCF / CLD / CKD

Ex
- Ca
-Infection
- Infarction
- inflammation RA / SLE

Exudative - Lights criteria
- Protein <30<
- albumin / plasma albumin >0.5
- Effusion LDH / Plasma LDH >0.6

Empyema
- Low glucose + pH <7.2

58
Q

Empyema management

A

Surgical drainage
IV Abx
Consider DNAse + TPA

59
Q

Lung Ca signs on exam? Complications

A

Inspect
Cachexia

Hands
- Clubbing
- Tar staining

Neck
- Cervical lymphadenopathy
- Tracheal deviation towards (collapse) or away (effusion)

Chest
- Collapse / consolidation / effusion

Complications on exam
[Neck down]
- SVCO - Odematous face, dilated veins, stridor
- Horners sign / T1 (small muscles of hand) wasting - pancoast
- Recurrent laryngeal nerve palsy - horse voice, bovine cough
- gynaecomastia - ectopic bHCG
- Lambert eaton myaesthenic syndrome / peripheral neuropathy / proximal myopathy / paraneoplastic cerebellar degeneration
- Derm - dermatomyositis

60
Q

What are the usual types of lung Ca?

A

Squamous 35%
small cell 24%
Adenocarinoma 21%
large cell 19%
alveolar 1%

61
Q

Name 3 ways to check cytology of lung Ca

A

Sputum cytolocy
BAL
Bronch biopsy
Perc biopsy

62
Q

Bloods which indicate complications of Lung Ca

A

Mets - HyperCa, LFTs, Anaemia

Squamous - PTH (releasing protein) - HyperCa

Small cell - ACTH -> SIADH + HypoNa

63
Q

Small cell vs Non small cell lung ca management

A

Small cell - usually just chemo

NSCLC - surgery / Radiotherapy / chemo

64
Q

What is this

A

Portacath
- Used for giving IVs

Attached as below

65
Q

Key signs on exam for CF

A

Small
Sputum pot
Possibly O2

Hands
- Clubbed
- Diabetes finger prick marks

Chest
- Hyperinflated
- Coarse crackles / wheeze
- Portacath / hickman

Abdo
PEG

66
Q

Cause of CF? Pathophysiology and organs affected

A

Ressessive chromosome 7 CFTR gene
delta 508 mutation
(1/2500 births)

Encodes cloride channels -> thickend secretions

Bronchioles -> Bronchiectasis
Pancreatic ducts - > exocrine / endocrine insufficiency. EG fat soluble vitamines / diabetes
Gut - > delayed transit
Gall bladder -> stones
Seminal vesicles -> infertility
Fallopian tubes -> infertility

67
Q

When does CF get screened for? other diagnostics

A

Birth - guthrie heel prick test

Cloride sweat test (>60mmol/L)

Genetic screening

68
Q

Who may the cloride sweat test be false positive in?

A

Hypothyroid

Addisons

69
Q

Management CF

A
  • Patient education
  • Regular sputum samples
  • Physio - inc postural drainage anbd breathing techniques
  • Dietician - vitamins +/- PEG feeding
  • Vaccines - esp pneumococcal and flu
  • Palliatve care

Medical
- Fat soluble vitamins
- creon
- abx for infections +/- prophylactic

70
Q

Most common bug in CF? Worst prognosis

A

Pseudomonas aeurginosa

Burkholderia cepacia

71
Q

When is CAP severe? what does this mean?

A

CURB 2 or more

Confusion
Urea >7
RR >30
BP less than 90/60
Age >65

IV antibiotics and level 2 care

72
Q

CAP investigations

A

Bloods - inflam
blood cultures

Sputum cultures

Urine
- Leigonella antigen
- penumococca antigen
- haemoglobinuria - mycoplasma -> haemolysis

73
Q

Pleural tap bits

A

pH <7.2 - infection / inflammatory
Protein
LDH
Cytology
BC bottles
glucose
TB

If bloody - worry about cancer

Consider amylase
If milky - cholesterol for cylothroax

74
Q

What is the lights criteria

A

If protein 25-35 can use lights
For exudate
Pleural fluid protein : serum >0.5
Pleural fluid LDH : Serum LDH >0.6
Pleural fluid LDH >2/3 serum exudate

75
Q

When might a transudative pleural effusion look exudative on lights

A

If heart failure and on lots of diuretics

76
Q

Options for management of recurrent malignant effusions

A

Indwelling pleural catheter

Talc pleurodesis

77
Q

Pleural biposy options

A

Can be US / CT guided

Option for VATS -> good as can add talc / indwelling catheter at end if needed

78
Q

how to manage a pleural effusion

A

It would depend on
- How symptomatic the patient is
- Size of the effusion (ideally on US)
- Do we have the underlying diagnosis yet

Likely
- CXR to confirm
- Then pleural aspirate for diagnosis and symptoms with CT.
- If I am worried about malignancy I would perform a CT CAP
- If an infection is worry for drain + inpatient antibiotics