Research Term Test 2 Flashcards

1
Q

4 levels of data

A
  1. nominal
  2. ordinal
  3. interval
  4. ratio
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2
Q

Nominal

A
  • allows to distinguish differences between items qualitatively
  • no quantitative ordering or value

assign responses to different categories

  • sex
  • marital status
  • postal code
  • university major
  • student ID
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3
Q

Ordinal

A
  • categories have logical order
  • starts at lowest and ends at highest
  • unknown numerical distance between catergories
  • Likert scales - allows for comparison in relative terms
  • ex. better or worse, smaller or larger
  • letter grade in class: F - A
  • Degrees held: BSc, MSc, PhD
  • perceived exertion
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4
Q

Interval

A
  • measurement are numerical values
  • intervals of equal length represent equal differences in characteristics
  • Zero, does not signify absence of characteristic (think temperature)
  • Starting point arbitrary
  • ex. behavioural questionnaires, IQ test
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5
Q

Ratio

A
  • allow for id of absolute differences
  • absolute zero
  • zero means absence of characteristic
  • most measured data first in this category
  • ex. BMI, weight, height, VO2, age, time to completion
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6
Q

Graphs - Describing data

A
  • simplest way for describing data
  • self-contained bundle of info
  • title indicating variables, clear id of categories and values, units of measurements indicated
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7
Q

Pie charts

A
  • distribution of cases in form of a circle
  • relative size of slice is proportional to proportion of cases within catergory
  • can be used for all levels of measurements
  • emphasize the relative importance of particular category to the total
  • difficult to interpret when there are too many categories (~~5 max)
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8
Q

Bar graphs & histograms

A

Horizontal axis: absicca

  • categories or values of the scale
  • independent variable

Vertical axis: ordinate

  • frequencies: raw count or percentage
  • calculated data
  • dependent vairable

Bar graphs

  • used when data is discrete (nominal or ordinal)
  • gaps between bars

Histogram:

  • sed when data is continuous (internal or ratio)
  • no gaps between bars
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9
Q

4 aspects of distribution

A
  1. shape
  2. centre
  3. spread
  4. existence of outliers
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10
Q

Shape of graphs

A
  • normal distribution
  • skewness describes if its shape is off centered to right or left
  • positive skewed (long tail to the right)
  • negative skewed (long tail to the left)
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11
Q

Center of graphs

A

place where equal number of score are on each side

- seen as the average

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12
Q

Spread of graphs

A
  • how tighly clustered the measurements aroudn the central point
  • wide spread = heterogenous scores = platykurtic
  • narrow spread = homogenous scores = leptokurtic
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13
Q

Outliers of graphs

A
  • upper and lower limits

- also ones that are disconnected from rest of the group

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14
Q

Descriptive statistics

A
  • used to characterize a group based on data taken from the group

Includes measures of:

  • central tendency: extent to which data clusters around a point
  • variability: extent to which data are spread out
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15
Q

Central tendencies

A
  • mean: arithmetic average of groups of numbers, calculated as sum of all numbers divided by total numbers of values in set
  • (limitation to mean): affected by presence of outliers, sum of values is pulled away from middle when data is skewed, can produce value that is higher or lower than expected
  • Median: single data value that resides in the middle of the data distribution
  • mode: most frequent score in a distribution (limitation: often does not represent actual middle of values)
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16
Q

Measures of variability/dispersion

A
  • range: difference between high and low score
  • standard deviation: estimate of spread of scores away from the mean
  • standard error of the mean: estimate of expected difference between sample mean and population mean
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17
Q

Inferential statistics

A

relationship between variables

useful example:

  • is there a relationship between a simple field test and a difficult lab test for a variable of interest?
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18
Q

Relationship between 2 variables

A
  • bivariate statistical analysis
  • a change in one variable is associated with a certain change in another
  • theoretical model - way to describe relationship
  • Ex. smoking history (independent) and health level (dependent)

Two ways:

  1. measure each variable separately
  2. measure association between variables
19
Q

Analyzing many variables

A
  • regression analysis
  • depict relationship between the dependent and 1 or more independent
  • asks how multiple known quantities affect dependent (unknown) quantity
  • creates one equation showing the relationship and allows to make predictions about dependent of a given individual, if you know all values for independent variables
20
Q

Categories of stats

parametric

A

used for interval and ratio data that meet following assumptions:

  • variable of interest must be normally distributed within pop
  • must have same variance within samples drawn from pop
  • score or measures of variable must be independent
21
Q

Categories of stats

nonparametric

A

used for nominal and ordinal, as well as for interval and ratio that do no meet assumptions stated above

22
Q

Significance in research

A
  • reject the null means real difference exists bewteen groups (if a= .05 and p= .049, reject null)
  • do not reject null means no group differences exist (if a= .05 and p= .52, do not reject null)
23
Q

PICO

A

P: Population, patient, problem: who are the patients and what is the problem?
I: intervention or exposure: what do we do to them and what are they exposed to?
C: Comparison: what do we compare the intervention with?
O: Outcome: what happens?

24
Q

Purpose of research proposal

A
  • provide action plan for study

- serves as contractual agreement between researchers and those who approved the proposal

25
Q

Who Approves the research proposal?

A
  • granting agency
  • institutional review board
  • faculty advisor and commitee
  • ethics boards
26
Q

Rationale for study

A
  • intros topic and makes clear the importance
  • explains how the results will fill gap in related literature
  • ends with problem statement and specific aims
27
Q

Research Questions or Problem Statement

A
  • focal point for study
  • IDs independent and dependent variables
  • should be of interest and importance
28
Q

Characteristics of research question

A
  • Novel: has not been answered
  • researchable: can be addressed through collection and analysis of data
  • practical: necessary equipment, expertise, access to participants, and time are available
  • clearly stated: written straightforward , readily comprehensible using appropriate research language
  • timely: addresses current problem or issue
  • in line with priorities of funding agency or institution
29
Q

Specific aims

A
  • two or more related research questions or problems being proposed for investigation within the same study
  • each specific aim has research hypothesis associated
30
Q

Methods for study

A
  • includes comprehensive description of proposed methods
  • level of detail should allow competent replication of study
  • written in future tense in proposal and past tense in thesis or dissertation or research paper manuscript
31
Q

Info regarding study participants

A
  • recruitment process
  • participation inclusion and exclusion criteria
  • selection procedures
  • informed consent docs
32
Q

In vitro studies (primary research)

A

Strengths:

  • intervention
  • can assess mechanism
  • strict control of experiment = high interval validity
  • can assess cause and effect

Weaknesses:

  • low external validity
  • not directly comparable to humans
33
Q

Epidemiological studies (primary research)

A

Strengths:

  • large data sets
  • high external validity
  • can assess relative risk and odds ratios

Weaknesses:

  • observational
  • hypothesis generating - not causal
  • little control = confounding variables = low internal validity
34
Q

Clinical trials (primary research)

A

Strengths:

  • highly controlled = high internal validity
  • intervention
  • can assess cause and effect
  • human participants

Weaknesses:

  • can be difficult to conduct on large size
  • expensive
  • can have selection bias
  • placebo effect
35
Q

Reviews (secondary research)

A

Strengths:

  • strict methodology
  • combines all available data sets
  • can asses effect size

Weaknesses:

  • no direct intervention
  • relies on data from others
36
Q

Codes in ethics

A

Nuremberg Code

  • 1947 code for biomedical reserach was first to focus on informed consent
  • direct response to what Nazis did in WWII
  • Not a law but is basis for laws in many countries

Helsinki Declaration
- 1964 declaration provided additional guidance in such areas the use of animals

37
Q

Ethical considerations in research

A
  • informed consent
  • ethics boards
  • confidentiality
  • plagiarism
  • data manipulation
  • publishing
38
Q

Framework for medical ethics

A
  • respecting autonomy, justice, doing no hard, using resources fairly
  • provide basic needs with best available healt care, protect from abuse, neglect, discrimination
  • aim to avoid/reduce harm and cost to promote benefits
39
Q

Informed Consent

A
  • well-documented informed consent is hallmark of ethical reserach
  • responsibility of the investigator to obtain the informed consent of prospective participant or consent of legal guardian
  • respects individual autonomy to participate or not participate
  • simple and easily understandable language prior to signing
  • provide participants with a copy
  • tell participants who’s conducting study
  • any benefits for the participant to be expected
  • any potential risks and have they have been managed
40
Q

Research Ethics Committees (REB or IRB)

A
  • protective barrier between researchers and participants
  • review if benefits justify risk
  • veto unethical research
  • confirm that certain groups have not over-researched
41
Q

Confidential Info

A
  • directly identifying info: name, SIN, health care
  • indirectly identifying info: birth date, physical characteristics
  • coded info: only people with key can access personal identifiers
  • anonymized info: coded and then key is destroyed so data cannot be re-linked
  • anonymous info: personal identifiers were never associated with data
42
Q

Plagiarism

A
  • dishonest act of presenting intellectual property as an original idea
  • unethical and illegal
  • either quote or paraphrase
  • cite original source unless its common knowledge
43
Q

Outliers (ethics)

A
  • defined as measurement or observation that is way out of line vs rest of data set
  • can results from error in data collection, bug in software, or participant who markedly differs from other participants
  • should be evaluated and discarded if bad
  • should not be discarded if legitimate data
  • may be considered outlier if >2-3 SD from mean