Research article reading

Question 1

Multipotent haematopoietic stem and progenitor cells (HSPCs) are the source for _.

Answer 1

all blood cell types

Question 2

The bone marrow stem cell niche in which the HSPCs are maintained is known to be _.

Answer 2

vital
for their maintenance

Question 3

_ in which the HSPCs are maintained is known to be vital for their maintenance.

Answer 3

The bone marrow stem cell niche

Question 4

Endosteal Niche: This niche is located _. It primarily involves interactions between . The endosteal niche is crucial for maintaining the quiescence () of HSCs and for regulating their _

Answer 4

near the inner surface of the bone (endosteum)
_
osteoblasts (bone-forming cells) and hematopoietic stem cells (HSCs).
_
a non-dividing state
_
differentiation into various types of blood cells.
_

Question 5

Perivascular Niche: This niche is found _. It is rich in cells like _. The perivascular niche supports the _ and is key for _.

Answer 5

surrounding the blood vessels within the bone marrow and other tissues
_
endothelial cells (which line blood vessels) and mesenchymal stem cells
_
proliferation and differentiation of HSCs
_
the mobilization of these cells into the bloodstream