Reproductive Immunology Flashcards
1
Q
Which immune cells are present at the implantation site?
A
NK cells (70%)
Macrophages (20%)
T-cells (10%)
2
Q
Cytokine profile according to pregnancy trimester
A
1st trimester: inflammation (Th1) essential for implantation
2nd: anti-inflammation (Th2) essential for placentation
3rd: inflammation (Th1) essential for parturition
3
Q
___ cells prevent inflammation allowing implantation
A
Dendritic
4
Q
Dendritic cells down-regulate ___ and up-regulate to prepare the endometrium for implantation
A
MUC-16 (down)
CD 44 (up)