reproductive endocrinology

Question 1

Somatic (post-zygotic) mutation of the G3 protein alpha subunit (GNAS1 gene)

Answer 1

McCune-Albright Syndrome(Donovan J McCune& Fuller Albright)

Question 2

Autonomous function of endocrine glands, ovarian follicular cysts, and altered osteoblast/osteoclast function.

Answer 2

McCune-Albright Syndrome(Donovan J McCune& Fuller Albright)

Question 3

Chimeric individuals with some cells having constitutive activation of the G protein that is coupled to multiple membrane-bound receptors – results in increased cAMP.

Answer 3

McCune-Albright Syndrome(Donovan J McCune& Fuller Albright)

Question 4

Suspect McCune–Albright syndrome when at least 2 features are present:

Answer 4

Polyostotic Fibrous dysplasia ,