Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmocolgy > Reproductive Drugs > Flashcards

Reproductive Drugs Flashcards

1
Q

how are most sex hormones made ?

A

steroid hormones- cholesterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is the steps of synthesis of cholesterol ?

A

cholesterol –> progesterone –> testosterone –> estradiol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

how do steroid hormones work ?

A

nuclear receptors through gene transcription

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What steroid hormone has a plasma membrane receptor ?

A

Oestrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the effect of oestrodiol ?

A

stimulate growth of endometrium and breast, releases progesterone receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the effect of progesterone?

A

stimulate growth of endometrium and breast, maintains pregnancy . inhibits oestrogen receptor
secretions of endometrium , mood change , increase bone density

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is the effect of oestrogen ?

A 
Anabolic 
sodium and water retention 
raises HDL, lowers LDL
decrease bone resorption - maintains high density
reduce bone resorption 
increase coagulation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what are side effects of oestrogen ?

A 
breast tenderness 
nausea / vomiting
water retention 
thromboembolism 
decreased glucose tolerance 
endometrial/ breast hyperplasia and cancer
ovarian metaplasia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are the side effects of progesterone ?

A

weight gain , fluid retention, Acne, nausea/ vomiting, depression , PMS and lack of concentration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what are the effects of testosterone ?

A

anabolic, acne , voice changes , aggression , increased HDL/LDL ratio

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

State 3 facts about the pharmokinetics of oestrogen

A

A- absorbed in GI tract and mucous membranes and Skin
D
M- Liver
E- urine = glucuronides and sulfates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

State 3 facts about the pharmokinetics of progesterone ?

A

A- Injected
D- Bound to albumin and adipose
M- Liver
E- urine via conjugated glucuronic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is a risk factors of COCP?

A

Thromboembolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Name some CYP450 inducers

A

carbamazepine , phenytoin
st john’s wort
rifampicin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what does soya do to oestrogen ?

A

increase absorption , reduce storage in adipose, T1/2 reduced to 7 hours from 15

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

when should you give HRT?

A

Menopause symptoms - hot flushes, Dyspareunia
osteoporosis , genital atrophy
not for Heart diease

17
Q

name 2 oestradiol drugs

A

Valerate , enanthate and premarin

18
Q

what are the route of administration for HRT?

A

Oral, transdermal, transvaginal, implant and nasal

19
Q

what is the main side effect of unopposed oestrogen therapy ?

A

Risk of endometrial/ ovarian cancers

- highly proliferative

20
Q

what is the main side effect of opposed oestrogen therapy ?

A

increases risk of breast cancer

21
Q

why does oral HRT lead to thromboemoblsim ?

A

increased resistance to protein C (anticoagulant)

increased thrombin , decreased anti thrombin 3 , decreased protein s , decreased factor 7 and decreased TF inhibitor

22
Q

what is the CV effect of HRT?

A

Increase HDL , reduce oxLDL and TAG and Lipop A

does not happen if patient is obese

23
Q

What Administration of HRT leads to increased risk of stroke ?

A

Oral

24
Q

what is Mifepristone ?

A

progesterone and glucocorticoid receptor antagonist

25
Q

what is the uses for Mifepristone ?

A

sensitising the myometrium to prostaglandin induced contraction
termination of pregnancy

26
Q

what is a SERM ?

A

Selective estrogen receptor modulator

agonists and antagonists mix

27
Q

what is Clomiphene treated for ? how does it work?

A

anovulation
competes binding with oestrogen
leads to increased FSH,LH Production = ovulation

28
Q

what is tamoxifen ?

A

pro drug SERM metabolised in liver

29
Q

what does tamoxifen do at each site ?

A

active metabolites –>
Endometrium = ER agonist
Breast= ER antagonist = cells arrest in cell cycle

30
Q

what is Ulipristal acetate and what is it used for ?

A

Selective progesterone receptor modulator
emergency contraception - MOA is delay of ovulation
used for fibroids as well .

Pharmocolgy (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions