Pharmacovigilance

Question 1

what is pharmacovigilance ?

Answer 1

identification, assessment and subsequent prevention of adverse drug reactions

Question 2

what molecules can easily cross the plancental barrier ?

Answer 2

tetragens

Question 3

what is the difference between Adverse drug reaction compared to adverse event

Answer 3

cause of ADR is due to the therapeutic but in event causality has not been confirmed

Question 4

Name a few features of Type A (Augmented) reaction

Answer 4

dose related
predicted from pharmacology
common and reversible

Question 5

name features of Type B reaction

Answer 5

Not dose related
uncommon
unpredictable
serious and irreversible

Question 6

read slide on DoTS

Answer 6

work out the Table of ADRs again

Question 7

what is DoTS?

Answer 7

Dose-related
time-related
Susceptibility (age, gender)
they help classify ADRs

Question 8

what are the 4 broad MOAs fro ADRs?

Answer 8

1. exaggerated response
2. desired effect at wrong site
3. secondary effect
4. triggers immune response

Question 9

what is in place by MHRA to report ADRs?

Answer 9

yellow card scheme

Question 10

what is responder rates ?

Answer 10

the rate at which a particular patient population do not respond to a drug

Question 11

What 2 things in PG can alter the Pharmacokinetics

Answer 11

Drug metabolism via CYP genes

Receptor efficacy