Reproductive Axis Flashcards
What hormone is released from the posterior pituitary and acts on the uterus?
Oxytocin
What type of receptor does Oxytocin bind to?
Gq alpha
What action does oxytocin binding cause?
Contraction
What type of receptor does GnRH bind?
Gq
What type of receptor does FSH and LH bind?
Gs
What three locations does LH act upon in women?
Thecal cell, Placenta, Corpus Luteum
What does the thecal cell produce?
Testosterone
What does testosterone from the thecal cell cause?
Alters transcription and causes feminization.
What does the placenta secrete?
Chorionic gonadotropin
What type of receptor does Chorionic gonadotropin bind?
Gs alpha
What is the function of Chorionic gonadotropin?
CL maintenance
What does the Corpus Luteum secrete?
Progesterone
Where does Progesterone from the Corpus Luteum act?
Alters transcription and acts at the uterus for pregnancy
What two locations does FSH act on in women?
Ovary (follicle) and Granulosa cell
What is produced from the ovary when FSH is released?
Ovum which aids in reproduction
What is produced from the Granulosa cell when FSH is released?
Inhibin and estradiol
What are the functions of Inhibin and estradiol in women?
Reduce FSH secretion
What two locations does LH act on in men?
Leydig and Sertoli cell
What do Sertoli cells release (LH) and what does it do?
Inhibin which reduces FSH secretion
What do Leydig cells release and what does it do?
Testosterone. It alters transcription and causes masculinization.
What locations does FSH act on in men?
Sertoli Cell
What does the Sertoli cell release in response to FSH and what does it do?
Sperm, reproduction
