Reproductive 8% Flashcards
Dysfunctional uterine bleeding
Excessive uterine bleeding with no demonstrable organic cause:
Polymenorrhea (cycles with intervals of 21 days or fewer),
menorrhagia (abnormally heavy or prolonged bleeding) and/or
metrorrhagia (uterine bleeding at irregular intervals)
Dysfunctional uterine bleeding diagnosis; treatment
Diagnosis of exclusion;
treat with oral contraceptives and NSAIDs
Endometrial cancer
Postmenopausal vaginal bleeding;
most common GYN malignancy - usually adenocarcinoma.
Endometrial cancer diagnosis
Endometrial biopsy - vaginal bleeding in post menopausal women is CA until proven otherwise.
Endometrial cancer treatment
Hysterectomy bilateral salpingo-oophorectomy +/- radiation.
Endometriosis
A disease in which the kind of tissue that normally grows inside the uterus grows outside the uterus. It can grow on the ovaries, fallopian tubes, bowels, or bladder. Rarely, it grows in other parts of the body. A benign disease related to the menstrual cycle, usually cyclical
Endometriosis findings
Uterus is fixed and retroflexed. Tender nodularity of cul de sac and uterine ligaments.
Endometriosis diagnosis; treatment
Laparoscopy: Chocolate cysts observed. Definitive study.
Treatment: Resect endometriosis, oral contraceptive therapy.
Endometriosis associated with the 3 D’s:
Dyspareunia (painful intercourse),
dyschezia (difficulty in defecating),
dysmenorrhea
Leiomyoma
Also known as fibroids, is a benign smooth muscle tumor that very rarely becomes cancer (0.1%).
Leiomyoma presentation
Black women, family history.
Abnormal uterine bleeding; polymenorrhea, menorrhagia, intermenstrual bleeding and/or metrorrhagia along with urinary symptoms (eg, urinary frequency or urgency).
Uterine mass.
Leiomyoma diagnosis; treatment
Ultrasound: Intramural fibroids are most common. Definitive treatment: myomectomy or hysterectomy.
Prolapse presentation
Caucasian women, after labor/delivery, chronic cough. Vaginal fullness, abdominal pain worse late in day, after prolonged standing. Relieved by lying down.
Prolapse, uterus
Prolapse of the uterus into the vaginal canal - graded by uterine descent: 0°- No descent. 1° - descent between normal and ischial spine. 2°- between ischial spines and hymen. 3°- within hymen. 4° - through hymen.
Prolapse, bladder
Prolapse of the bladder into the front wall of the vagina (cystocele) - leads to a “reservoir effect” where the bladder is not completely emptied when the urine is passed.
Prolapse, rectum
Prolapse of the rectum into the back wall of the vagina (rectocele) - complain of a sensation of bulging in the vagina when they strain to open their bowels.
Ovarian Cysts
Pain, menstrual delay, hemorrhagic shock from cyst rupture. Follicular cysts are most common.
Ovarian Cysts diagnosis; treatment
Ultrasound.
Observe - Most resolve within 6-8 weeks (2 menstrual cycles). Persistent cysts, large cysts (>6 cm) or complex cysts can be removed.
PolyCystic Ovary Syndrome (PCOS)
Obesity, hirsutism, acne, amenorrhea or oligomenorrhea, menarche occurs at expected age. Strongly associated with obesity, acanthosis nigricans, insulin resistance and hyperinsulinemia.
PolyCystic Ovary Syndrome (PCOS) diagnosis; treatment
Ultrasound: String of pearls. Labs: LH:FSH > 2.0, increased androgens, increased testosterone.
Treat with oral contraceptives, metformin.
Ovarian Neoplasms
Patient in mid-50’s with abdominal fullness, bloating, fatigue, weight loss and ascites.
Ovarian Neoplasms diagnosis; treatment
Tumor marker: CA 125, second most common gynecological cancer (first is endometrial).
Asymptomatic premenopausal patients with simple ovarian cysts < 10 cm in diameter can be observed or placed on suppressive therapy with oral contraceptives.
Postmenopausal women with simple cysts < 3 cm in diameter may also be followed, provided the serum CA 125 level is not elevated and the patient has no signs or symptoms suggestive of malignancy. If the cyst is > 3 cm or the CA 125 is elevated, further evaluation is necessary.
Cervical cancer exam
Friable, bleeding cervical lesion.
Cervical cancer etiology
Squamous cell carcinoma. Most caused by HPV (High risk types, 16 and 18).
Cervicitis etiology
Usually occurs due to sexually-transmitted diseases, such as chlamydia or gonorrhea, herpes, HPV, trichomonas
Cervicitis exam
Cervical motion tenderness
Cervicitis treatment
Azithromycin for Chlamydia + Ceftriaxone for gonorrhea
Cervical Dysplasia
HPV especially types 16, 18. Associated with cigarette smoking. Transformational zone most commonly affected.
Cervical Dysplasia vaccine; diagnosis; treatment
Gardasil vaccine at age 11-12 it can be administered starting at 9 years of age.
Pap smear every 3 years starting at age 21 (regardless of sexual activity). Every 5 years if pap smear and HPV are negative starting at age 30.
ASC-US or LSIL, CIN-1: Reflex HPV, if positive and at least 25 years old – colposcopy, if negative or under 25 years old – retest in 1 year.
HSIL, CIN-2, CIN-3, CIS: Colposcopy. Outside cervix – LEEP or cryotherapy
Incompetent Cervix
History of cone biopsy, DES [Diethylstilbestrol (DES), also known formerly as stilboestrol, is a synthetic nonsteroidal estrogen] exposure.
Causes 2nd trimester abortion.
Cervical cerclage. Placed at 14-16 weeks and removed at 36 weeks to allow for delivery
Cystocele (bladder hernia)
Prolapse of the bladder into the front wall of the vagina - leads to a “reservoir effect” where the bladder is not completely emptied when the urine is passed.
Vaginal cancer
Abnormal vaginal bleeding.
Squamous cell carcinoma caused by HPV.
Vulvar Cancer
Vaginal pruritis is most common presentation.
Squamous cell and melanoma > pruritic black lesions. Paget’s > pruritic red lesions.
Vaginal Prolapse
Feeling of vaginal or pelvic pressure, heaviness, bulging, bowel or bladder symptoms. Common after hysterectomy.
Baden-Walker grades of female genital prolapse – uses the hymen as crossing point
Grade 1 – descent above the hymen, Grade 2 – descent to the hymen, Grade 3 – descent beyond the hymen, Grade 4 – total prolapse
Rectocele
Prolapse of the rectum into the back wall of the vagina - complain of a sensation of bulging in the vagina when they strain to open their bowels
Vaginitis, Trichomonas
Frothy yellow, green, gray vaginal discharge and strawberry cervix.
Wet mount: Flagellated protozoa. pH: Basic.
Treatment: Metronidazole
Vaginitis, Bacterial vaginosis
Organism: Haemophilus, aka Gardnerella.
Signs: Fishy odor, thin gray discharge.
Wet mount: Clue cells. pH: Basic 4.5
Treatment: Metronidazole.
Vaginitis, Candida
Thick white vaginal discharge. Associated with recent antibiotic use, diabetes mellitus, steroid use.
KOH prep: Pseudohyphae. pH: Normal 4.
Treatment: Fluconazole
Amenorrhea, primary
No menses by age 16.
Turner’s syndrome – XO karyotype, webbed neck, broad chest.
Androgen insensitivity – breast development only. Imperforate hymen – observed on speculum exam. Mullerian agenesis – secondary sex characteristics, no uterus
Amenorrhea, secondary
Previously had menses, amenorrhea for 6 months.
Most often pregnancy. Also caused by weight changes, hypothyroid, prolactinoma.
Dysmenorrhea
Pain with menses or precede menses by 1 to 3 days. Pain tends to peak 24 h after onset of menses and subsides after 2 to 3 days.
Dysmenorrhea, primary
Begins early after menarche, not associated with pelvic pathology, associated with prostaglandins, treatment with NSAIDs and oral contraceptive pills
Dysmenorrhea, secondary
New onset in an older women, associated with a secondary pathologic (structural) cause - adenomyosis, endometriosis, fibroid, PID, IUD, treat underlying cause.
Premenstrual syndrome (PMS)
Caused by an imbalance of estrogen and progesterone along with excess prostaglandin production.
Symptoms during luteal phase (1-2 weeks before menses) - Bloating, irritability. PMDD - causes marked disruption in functioning.
Symptoms resolve at the onset of menses.
Menopause
Menopause is a clincal diagnosis and is defined by cessation of menses for at least 12 months.
Average age is 51.5.
Menopause diagnosis; treatment
Definitive diagnosis: FSH > 30 mIU/mL
Women who have a uterus should be given a progestin in addition to estrogen because unopposed estrogen increases risk of endometrial cancer.