Endocrinology 6% Flashcards
Hyperparathyroidism, primary
↑ PTH usually caused by a PTH secreting parathyroid ADENOMA
Hyperparathyroidism, secondary
↑ PTH by a physiologic response to hypocalcemia or vitamin D deficiency.
Chronic kidney disease is the most common cause of secondary hyperparathyroidism.
Hyperparathyroidism, presentation:
“stones, bones, abdominal groans, psych moans, fatigue overtones”:
Nephrolithiasis, DI, bone pain, arthralgia, PUD, constipation, depression, fatigue.
Hyperparathyroidism, labs
Hypercalcemia ↑ CA+, ↓ phosphorus, elevated ↑ PTH, and moderately elevated urinary calcium.
Hyperparathyroidism, treatment
Acute - Saline, calcitonin, bisphosphonates.
Definitive - Surgical correction. Remove overactive parathyroid gland. If all 4, remove 3.5 glands.
Hypoparathyroidism, presentation
Tingling, Tetany, cataracts.
Hypoparathyroidism, signs
Chvostek’s sign: tap facial nerve illicit cheek twitch.
Trousseau’s sign: BP cuff inflation illicit carpal spasm.
Hypoparathyroidism, labs
Hypocalcemia ↓ CA+, low ↓ PTH, hyperphosphatemia, low urinary calcium.
Hypoparathyroidism, etiology
Two most common etiologies are postsurgical (damage from neck or thyroid surgery) or autoimmune.
Hypoparathyroidism, treatment
Vitamin D and Calcium
Tetany- secure airway, IV calcium gluconate
Hyperthyroidism, etiology
Grave’s disease (autoimmune). Toxic adenoma, thyroiditis, pregnancy, amiodarone.
Hyperthyroidism symptoms
Heat intolerance, palpitations, sweating, weight loss, tremor, anxiety, tachycardia.
Hyperthyroidism, Grave’s signs
Diffuse goiter with a bruit, exophthalmos, pretibial myxedema.
Hyperthyroidism, Thyroid storm
Fever, tachycardia, delirium.
Hyperthyroidism, diagnosis
TSH (best test): Decreased in primary disease (↓ TSH and ↑ Free T4), elevated in secondary disease (↑ TSH and ↑ Free T4).
Thyroid radioactive iodine uptake:
Graves: Diffusely high uptake.
Toxic multinodular: Discrete areas of high uptake.
Grave’s - Thyrotropin receptor antibodies (TRAb, also called TSI, TBII, or TBI).
Hyperthyroidism, treatment
Beta-blockers (symptomatic), methimazole/propylthiouracil, radioactive iodine, thyroidectomy.
Hypothyroidism, etiology
Hashimoto’s (chronic lymphocytic/autoimmune), previous thyroidectomy/iodine ablation, congenital.
Hypothyroidism, symptoms; signs
Cold intolerance, fatigue, constipation, depression, weight gain, bradycardia.
Congenital: round face, large tongue, hernia, delayed milestones, poor feeding.
Hypothyroidism, diagnosis
TSH is elevated in primary disease. Low T4 (↑ TSH and ↓ Free T4).
Hashimoto’s: Antithyroid peroxidase (TPO), antithyroglobulin antibodies (Tg).
Hypothyroidism, treatment
Levothyroxine. Follow up with serial TSH monitoring.
Thyroid neoplastic disease, findings
Hoarse voice; cold nodule on thyroid uptake scan.
Most often papillary carcinoma (80%).
Thyroid neoplastic disease, diagnosis
Usually normal thyroid function.
Ultrasound is the best initial screen followed by a thyroid uptake scan.
Microcalcifications, hypoechogenicity, a solid cold nodule, irregular nodule margins, chaotic intranodular vasculature, and a nodule that is more tall than wide.
Fine needle biopsy for definitive diagnosis (all lesions >1 cm should be biopsied).
Thyroid neoplastic disease, treatment
Surgical resection with chemotherapy and external beam radiation reserved for anaplastic thyroid cancer.
Thyroiditis
Painful vs. Painless may be hypo or hyperthyroid
Hashimoto’s thyroiditis
Diffusely enlarged, painless, nodular goiter.
Subacute thyroiditis
Young women, after a viral infection.
Painful enlarged thyroid with dysphagia, mild fever.
Aspirin.
Postpartum thyroiditis
1-2 months of hyperthyroidism after delivery.
Completely resolves, give propranolol for cardiac symptoms.
Suppurative thyroiditis
Fever, pain, redness, fluctuant mass.
↑ WBC.
Antibiotic/surgical drainage.
Corticoadrenal insufficiency (Addison’s Disease)
Typically autoimmune. May be due to Tuberculosis in endemic areas.
Destruction of the Adrenal cortex resulting in loss of cortisol production (↓ cortisol).