Reproductive

Question 1

Bartholin gland cyst: unilateral painful cystic lesion at ________ (anatomic location)

Answer 1

lower vestibule adjacent to the vaginal canal

Question 2

lichen sclerosis:
thinning of the ____ and fibrosis/sclerosis of the _____ of the vulva=> leukoplakia with parchment like vulvar skin

benign? malignant? increased risk for cancer?

Answer 2

thinning of the epidermis and fibrosis/sclerosis of the dermis

benign, but slightly increased risk for squamous cell carcinoma

Question 3

leukoplakia with leathery vulvar skin, associated w/ chronic irritation and scratching

dx? histo? benign or malignant? increased risk for cancer?

Answer 3

lichen simplex chronicus
hyperplasia of vulvar squamous epithelilum
benign, no increased risk of carcinoma

Question 4

melanomas are keratin positive or negative?

Answer 4

NEGATIVE

Question 5

associated w/ females exposed to DES in utero

Answer 5

adenosis, which can lead to

clear cell adenocarcinoma

Question 6

if vaginal carcinoma from lower 1/3 of vagina spreads to lympho nodes, it goes to the _____ nodes

if cancer is in upper 2/3, it goes to _____ nodes

Answer 6

lower 1/3 = inguinal nodes

upper 2/3 = iliac nodes

Question 7

all of vagina mucosa is lined by nonkeratinizing squamous epithelium.
exocervix is lined by _______
endocervix = __________

Answer 7

exocervix = nonkeratinizing squamous epithelium (same as vagina)

endocervix = columnar

Question 8

high risk HPV has E6 and E7 proteins which do what?

Answer 8

E6 = destroy p53

E7 = destroy Rb

Question 9

double/triple therapy for acute endometritis

Answer 9

gentamicin
clindamycin
+/- ampicillin

Question 10

what cells must you see to dx chronic endometritis (vs acute)

Answer 10

plasma cells

b/c lymphocytes are normally found in endometrium!

Question 11

tamoxifen vs raloxifen estrogen antagonist and agonist where?

Answer 11

both are antagonist in breast and agonist in bone. but tamoxifen is agonist in endometrium and raloxifen is antagonist