Reproductive Flashcards
1
Q
2 Drugs Inhibit Testosterone Production
A
Ketoconazole: inhibit steroid synthesis
Spironolactone: inhibit synthesis and binding
2
Q
Drug that inhibits DHT Production
A
Finasteride: inhibits 5 alpha reductase
3
Q
Drug that inhibit Testos and DHT on androgen-R
A
Flutamide: competitive inhibitor at androgen-R
Spironolactone: inhibit steroid binding
Cyproterone
4
Q
Testosterone Toxicity
A
Masculinization of female
Gonadal atrophy
Premature closure epiphyseal plates
Increased LDL, decreased HDL
5
Q
Finasteride Treats
A
BPH
Male patterned balding
6
Q
Flutamide Treats
A
Prostate carcinoma
7
Q
Ketoconazole and Spironolactone Treat
A
PCOS - prevent hirsuitism
Tox: gynecomastia, amenorrhea
