Pharmacology

Question 1

Alpha 1

Answer 1

1. Vasoconstriction
2. Mydriasis
3. Intestinal and bladder sphincter contraction

Question 2

Alpha 2

Answer 2

Decreases sympathetic tone: (-) feedback

Decrease Insulin release

Question 3

Beta 1

Answer 3

Inc. HR
Inc. Contractility
Inc. lipolysis
Inc. renin release

Question 4

Beta 2

Answer 4

Bronchodilation
Vasodilation (reflex tachycardia, cont)

Inc. insulin release
Dec. uterine tone (tocolytic)
Inc. aqueous humor production

Question 5

M1

Answer 5

CNS

Enteric NS

Question 6

M2

Answer 6

Dec. HR

Dec. Contractilty

Question 7

M3

Answer 7

Inc. Gland secretion 
Inc. gut peristalsis 
Inc. bladder contraction 
Bronchoconstriction 
Miosis
Accomodation

Increase Insulin

Question 8

D1

Answer 8

Kidneys - relaxes vascular smooth muscle

Question 9

D2

Answer 9

CNS - modulates transmitter release

Question 10

H1

Answer 10

Allergy Sx:

Inc. Nasal and Bronchial mucus production
Inc. Vascular permeability
Inc. contraction bronchioles
Pruritis, Pain

Question 11

H2

Answer 11

Inc. Gastric Acid Secretion

Question 12

V1

Answer 12

vasoconstriction

Question 13

V2

Answer 13

kidney - Inc. H20 permeability and reabsorption in collecting tubules (V2 for 2 kidneys)

Question 14

G protein coupler receptors

Answer 14

Gq: HAV1 M1&M3
Gi: MAD2
GS: everything else

Question 15

Hemicholinium

Answer 15

Inhibit Choline-Na transporter

Question 16

Vesamicol

Answer 16

Inhibit Ach packaging into vesicles

Question 17

Botulinum

Answer 17

Inhibit exocytosis of Ach

Question 18

Black Widow Spider Toxin

Answer 18

Stimulate exocytosis of Ach

Question 19

Metyrosine

Answer 19

Inhibit Tyrosine hydroxylase: Tyr –> L-DOPA

Question 20

Reserpine

Answer 20

Inhibit NE packaging into vesicles

Question 21

Drugs that stimulate NE release

Answer 21

Amphetamine
Tyramine
Ephedrine

Question 22

Drugs that inhibit NE Reuptake

Answer 22

Cocaine

TCA

Question 23

Drugs that inhibit NE exocytosis

Answer 23

Bretylium

Guanethidine

Question 24

Metabolism of NE

Answer 24

COMT
MAO

Dopa -> HVA
NE -> VMA
Epi -> Metanephrine

Question 25

Direct Ach Agonist: Cholinomimetic agents (4)

Answer 25

Bethanechol - postop ileus, urinary retention Carbachol- Glaucoma Methacholine- asthma challenge Pilocarpine - stimulator of sweat, tears, saliva. "you cry, drool, and sweat on your PILOws"

Question 26

Neostigmine

Answer 26

Anticholinesterase - postop ileus - urinary retention - MG Neo CNS = NO CNS penetration

Question 27

Pyridostigmine

Answer 27

MG

Question 28

Physostigmine

Answer 28

Atropine OD Does cross BBB.

Question 29

Donepezil, Rivastigmine, Galantamine

Answer 29

Alzheimer's disease

Question 30

Edrophonium

Answer 30

Tensilon test

Question 31

Exacerbation of what diseases may occur with cholinomimetic agents

Answer 31

COPD, asthma, peptic ulcers

Question 32

Atropine, Homatropine, Tropicamide

Answer 32

Muscarinic Antagonist Mydriasis and cycloplegia of eye

Question 33

Benztropine

Answer 33

Muscarinic Antagonist Parkinson's: Park my Benz

Question 34

Scopolamine

Answer 34

Muscarinic Antagonist Dec. oral secretions Motion sickness

Question 35

Ipratropium, Tiotropium

Answer 35

Muscarinic Antagonist COPD, asthma

Question 36

Drugs that decrease overactive bladder/urge incontinence

Answer 36

"On The Darn Toilet" Muscarinic Antagonist Oxybutynin Tolterodine, Trospium Darifenacin, Solifenacin

Question 37

Glycopyrrolate

Answer 37

Muscarinic Antagonist

Question 38

Epinephrine

Answer 38

All 4 sympathomimetics Beta > alpha Anaphylaxis

Question 39

NE

Answer 39

alpha 1 > alpha 2 > beta1 Hypotension

Question 40

Isoproterenol

Answer 40

beta 1 = beta 2

Question 41

Dopamine

Answer 41

D1 = D2 > beta > alpha low doses > med doses > high doses Heart failure, shock

Question 42

Dobutamine

Answer 42

beta 1 > beta 2 > alpha Heart failure Cardiac stress testing

Question 43

Phenylephrine

Answer 43

alpha 1 > alpha 2 Rhinitis

Question 44

Albuterol, Salmeterol, Terbutaline

Answer 44

beta 2 > beta 1 Acute asthma