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First Aid/DIT > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Alpha 1

A
  1. Vasoconstriction
  2. Mydriasis
  3. Intestinal and bladder sphincter contraction
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2
Q

Alpha 2

A

Decreases sympathetic tone: (-) feedback

Decrease Insulin release

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3
Q

Beta 1

A

Inc. HR
Inc. Contractility
Inc. lipolysis
Inc. renin release

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4
Q

Beta 2

A

Bronchodilation
Vasodilation (reflex tachycardia, cont)

Inc. insulin release
Dec. uterine tone (tocolytic)
Inc. aqueous humor production

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5
Q

M1

A

CNS

Enteric NS

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6
Q

M2

A

Dec. HR

Dec. Contractilty

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7
Q

M3

A 
Inc. Gland secretion 
Inc. gut peristalsis 
Inc. bladder contraction 
Bronchoconstriction 
Miosis
Accomodation

Increase Insulin

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8
Q

D1

A

Kidneys - relaxes vascular smooth muscle

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9
Q

D2

A

CNS - modulates transmitter release

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10
Q

H1

A

Allergy Sx:

Inc. Nasal and Bronchial mucus production
Inc. Vascular permeability
Inc. contraction bronchioles
Pruritis, Pain

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11
Q

H2

A

Inc. Gastric Acid Secretion

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12
Q

V1

A

vasoconstriction

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13
Q

V2

A

kidney - Inc. H20 permeability and reabsorption in collecting tubules (V2 for 2 kidneys)

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14
Q

G protein coupler receptors

A

Gq: HAV1 M1&M3
Gi: MAD2
GS: everything else

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15
Q

Hemicholinium

A

Inhibit Choline-Na transporter

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16
Q

Vesamicol

A

Inhibit Ach packaging into vesicles

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17
Q

Botulinum

A

Inhibit exocytosis of Ach

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18
Q

Black Widow Spider Toxin

A

Stimulate exocytosis of Ach

19
Q

Metyrosine

A

Inhibit Tyrosine hydroxylase: Tyr –> L-DOPA

20
Q

Reserpine

A

Inhibit NE packaging into vesicles

21
Q

Drugs that stimulate NE release

A

Amphetamine
Tyramine
Ephedrine

22
Q

Drugs that inhibit NE Reuptake

A

Cocaine

TCA

23
Q

Drugs that inhibit NE exocytosis

A

Bretylium

Guanethidine

24
Q

Metabolism of NE

A

COMT
MAO

Dopa -> HVA
NE -> VMA
Epi -> Metanephrine

25
Q

Direct Ach Agonist: Cholinomimetic agents (4)

A

Bethanechol - postop ileus, urinary retention

Carbachol- Glaucoma

Methacholine- asthma challenge

Pilocarpine - stimulator of sweat, tears, saliva. “you cry, drool, and sweat on your PILOws”

26
Q

Neostigmine

A

Anticholinesterase

  • postop ileus
  • urinary retention
  • MG

Neo CNS = NO CNS penetration

27
Q

Pyridostigmine

A

MG

28
Q

Physostigmine

A

Atropine OD

Does cross BBB.

29
Q

Donepezil, Rivastigmine, Galantamine

A

Alzheimer’s disease

30
Q

Edrophonium

A

Tensilon test

31
Q

Exacerbation of what diseases may occur with cholinomimetic agents

A

COPD, asthma, peptic ulcers

32
Q

Atropine, Homatropine, Tropicamide

A

Muscarinic Antagonist

Mydriasis and cycloplegia of eye

33
Q

Benztropine

A

Muscarinic Antagonist

Parkinson’s: Park my Benz

34
Q

Scopolamine

A

Muscarinic Antagonist

Dec. oral secretions
Motion sickness

35
Q

Ipratropium, Tiotropium

A

Muscarinic Antagonist

COPD, asthma

36
Q

Drugs that decrease overactive bladder/urge incontinence

A

“On The Darn Toilet”
Muscarinic Antagonist

Oxybutynin
Tolterodine, Trospium
Darifenacin, Solifenacin

37
Q

Glycopyrrolate

A

Muscarinic Antagonist

38
Q

Epinephrine

A

All 4 sympathomimetics
Beta > alpha

Anaphylaxis

39
Q

NE

A

alpha 1 > alpha 2 > beta1

Hypotension

40
Q

Isoproterenol

A

beta 1 = beta 2

41
Q

Dopamine

A

D1 = D2 > beta > alpha
low doses > med doses > high doses

Heart failure, shock

42
Q

Dobutamine

A

beta 1 > beta 2 > alpha

Heart failure
Cardiac stress testing

43
Q

Phenylephrine

A

alpha 1 > alpha 2

Rhinitis

44
Q

Albuterol, Salmeterol, Terbutaline

A

beta 2 > beta 1

Acute asthma

First Aid/DIT (5 decks)

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