Reproduction

Question 1

function of FSH in men

Answer 1

causes spermatogenesis in testes

Question 2

function of LH in men

Answer 2

causes testosterone secretion by the testes

Question 3

function of FSH in women

Answer 3

causes follicle growth and oestrogen secretion

Question 4

function of LH in women

Answer 4

causes ovulation, and causes corpus luteum to make progesterone

Question 5

how does oestrogen influence LH release?

Answer 5

oestrogen causes high freq pulsation of GnRH, stimulating LH release (surge!!)

Question 6

how does progesterone influence FSH release?

Answer 6

progesterone causes low freq pulsation of GnRH, stimulating FSH release

Question 7

how soon after the LH surge is ovulation?

Answer 7

about 34 hours

Question 8

true or false: oestrogen causes

• thinner vaginal wall
• fertile fluid
• increased vaginal pH

Answer 8

False - thickened wall
True - thin cervical mucus
False - decreased pH, more lactic acid

Question 9

does LH bind to theca or granulosa cells?

Answer 9

theca

Question 10

FSH causes progesterone formation - T / F ?

Answer 10

FSH causes oestrogen

LH causes progesterone

Question 11

effects of progesterone on…

• smooth muscle
• body temperature
• endometrium

Answer 11

relaxes muscle
increases temp
thickens the enodetrium

Question 12

what genetic abnormality causes amenorrhea?

Answer 12

Turners

Question 13

high levels of what hormone in the blood causes secondary amenorrhea?

Answer 13

Hyperprolactinaemia

Question 14

wtf is Hypogonadotrophic hypogonadism.. ?

Answer 14

type 1 - hypothalamic pituitary failure.

Question 15

oligomenohea occurs in hypogonadotrophic hypogonadism - true?

Answer 15

false - always amenorrhea

Question 16

what is more common - hypothalamic pituitary failure or dysfunction?

Answer 16

dysfunction = 85%

Question 17

treatment option for premature ovarian failure?

Answer 17

HRT - not that successful

Question 18

what hormone causes PCOS?

Answer 18

Excess LH !!

leads to excess androgens and insulin resistance

Question 19

what “C.C” is first line treatment of PCOS?

Answer 19

Clomifene Citrate

Question 20

what is a downside of clomifene citrate?

Answer 20

20% of women are resistant to it

Question 21

what is 2nd line treatment for PCOS?

Answer 21

Daily injection of gonadotrophins - directly stimulate the ovaries

Question 22

what is a risk of gonadotrophin injection for infertility in PCOS?

Answer 22

higher risk of twins

Question 23

what surgery can be attempted to combat infertility in PCOS?

Answer 23

Laproscopic ovarian diathermy

Question 24

is metformin effective in PCOS?

Answer 24

yes!!

can stimulate ovulation and help with androgen symptoms as well as insulin resistance

Question 25

sperm are made in….

• Leydig cells
• Sertoli cells
• seminiferous tubules

Answer 25

seminiferous tubules

Sertoli cells are part of this but they only make ABG

Question 26

how and when is testosterone made?

Answer 26

when LH binds to Leydig cells causing cholesterol conversion –> T

Question 27

90% of testosterone is taken up by Sertoli cells - what action does it have?

Answer 27

causes release of mature sperm from sertoli

Question 28

What controls the BTB?

Answer 28

blood testes barrier controlled by TESTOSTERONE AND FSH

Question 29

where are Leydig cells ?

Answer 29

interstitial - between the seminiferous tubules