Classifications of Diabetes

Question 1

why do 1/3 of acromegaly patients have diabeetus??

Answer 1

excess growth hormone can cause insulin resistance (as well as hepatic gluconeogenesis and glygogenolysis)

Question 2

why do cushings patients get diabetes?

Answer 2

excess cortisol causes poor muscle uptake of glucose, and increases hepatic gluconeogenesis

Question 3

why do pheochromocytoma patients get diabetes?

Answer 3

excess adrenaline / noradrenaline inhibits insulin secretion and increases glycogenolysis + lipolysis

Question 4

autoimmune conditions closely associated with T1?

Answer 4

coeliac and thyroid - both 5% raised from 1%

20% of CF get DM

Question 5

is MODY…

a) auto recc
b) auto dom
c) x linked
d) sporadic

Answer 5

b - auto dom :)

Question 6

what causes MODY 3?

Answer 6

HNF 1 alpha mutation

Question 7

what causes MODY 1?

Answer 7

HNF 4 alpha mutation

Question 8

what causes MODY 2?

Answer 8

glucokinase mutation

Question 9

rank the 3 most common MODYs

Answer 9

1st - MODY 3
2nd - MODY 2
3rd - MODY 1

Question 10

treatment of MODY 1 and 3?

Answer 10

diet - oral (SU mostly as still have functional b cells) - insulin
as it progresses

Question 11

treatment of MODY 2?

Answer 11

Diet only!!

normally stable with no complications

Question 12

what it the Tx for the two types of neonatal diabetes?

Answer 12

Transcient = insulin until resolves around 12 weeks
permanent = life long insulin / oral hyperglycaemic agents

Question 13

what does the mutation affect in neonatal diabetes?

Answer 13

the K channel

Question 14

describe who classically gets LADA

Answer 14

I’m a MAN who has recently bought a house in the local area with my other autoimmune conditions. I am 25-40.

Question 15

three pancreatic diseases that can lead to diabetes

Answer 15

haemochromatosis
CF
pancreatitis