Repro: Coitus Flashcards

1
Q

What changes to spermatids have to undergo to become spermatozoa?

A

The head undergoes nuclear condensation

The acrosome develops golgi-apparatus to make hydrolytic enzymes that enable penetration of the ovum

The mid piece has mitochondria packed around contractile filaments

There is a flagellum produced (tail)

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2
Q

What happens if sperm in the epididymis is not expelled?

A

Can be stored for several months but is phagocytosed by the epithelial cells

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3
Q

List the 4 phases of coitus

A
  • excitement
  • plateau
  • orgasmic
  • resolution
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4
Q

Describe the excitement phase in the male

A

Stimulation causes activation of sacral parasympathetic neurones and inhibits thoracolumbar sympathetic neurones.

The release of Ach binds to M3 receptors on endothelial cells which increases Ca and causes NO production.

NO causes vasodilation in the corpus cavernosa so there is increased blood flow causing erection.

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5
Q

Outline the plateau phase in the male

A

There is activation of the sacrospinous reflex which causes contraction of the ischiocavernosus at the base of the penis which causes venous engorgment.

The cowper’s glands are stimulated and secrete substances to lubricate and neutralise the urethra

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6
Q

Describe the emission phase in males

A

There is stimulation of the thoracolumbar sympathetic reflex which causes the smooth muscle in the vas deferens, ampulla of rectum and prostate to contract .

The internal and external urethral sphincters contract to prevent retrograde ejaculation

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7
Q

Describe the ejaculation phase in males

A

The sympathetic nervous system (L1,2) causes contraction of glands and ducts
The filling of internal urethra stimulates the pudendal nerve which causes contraction of the ischiocavernosus and bulbocavernosus which expels the semen
The anal sphincter contracts

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8
Q

Describe the resolution phase in males

A

There is activation of the thoracolumbar sympathetic pathway which causes contraction of the arteriolar smooth muscle in the corpus cavernosum
There is increased venous return and the penis becomes flaccid
No further orgasm is possible

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9
Q

Describe the excitement phase in the female

A

There is activation of sacral parasympathetic neurones and inhibition of thoracolumbar sympathetic neurones.

The clitoris engorges with blood and the uterus elevates. The inner 2/3rds of the vagina lengthens and expands to accommodate a penis

There is vaginal lubrication

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10
Q

Describe the plateau phase in females

A

There is further increase in muscle tone, heart rate and blood pressure

The labia minors deepen in colour due to increased blood flow and the clitoris withdraws under its hood.

There is bartholins gland secretion to lubricate the vestibule

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11
Q

Describe the plateau phase in females

A

The uterus is fully elevated and the inner 2/3rds of the vagina is fully distended

The outer 1/3 of the vagina forms the orgasmic platform - smooth muscle contracts

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12
Q

Describe the orgasm phase in females

A

The orgasmic platform (outer 1/3 of vagina) rhythmically contracts 3-15 times. The inner 2/3rds remains motionless

The uterus and anal sphincter contracts
The clitoris remains retracted under its hood.

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13
Q

Describe the resolution phase in females

A

There isnt one - multiple orgasms are possible

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14
Q

What is the G spot?

A

An area of erotic sensitivity on the anterior wall of the vagina.

The tissue is similar to that of the prostate so fluid released during ejaculation may be similar to prostatic secretions

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15
Q

What happens to the female sexual response with ageing?

A

(Particularly at the time of menopause)

  • Some women report reduced desire
  • Reduced vasocongestion so less vaginal lubrication
  • loss of elasticity of vaginal and urethral tissue
  • length and width of vagina decrease
  • number of orgasmic contractions reduced
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16
Q

What are some general causes of loss of desire?

A
  • age can cause a loss in sexual desire

- aversion : repulsion or fear of sex as a result of abuse

17
Q

What is the physical consequence of lack of arousal in females and males?

A

Females: lack of lubrication
Males: impotence

18
Q

What can cause impotence in men?

A
  • psychological
  • tears in the fibrous tissue of the corpus cavernosa
  • vascular causes eg athersclerosis or diabetes
  • alcohol
  • beta blockers
19
Q

How does viagra work?

A

Inhibits cGMP breakdown in the corpus cavernosa

This increases NO which stimulates vasodilation leading to increased penile blood blow and erection.

20
Q

What is the normal volume of semen produced per ejaculate?

How many sperm does this contain?

A

Normally 2-4ml of semen produced

There is approx 20-200 milllion sperm per ml so 40-800 million per ejaculate

21
Q

What is the medical for a sperm count <20 million per ml?

A

Oligozoospermia

22
Q

Outline the maturation of the oocyte nucleus?

A

The oocyte undergoes meiosis 1 and the nuclear membrane disappears

The first polar odd separates and enters the perivitelline space

A second meitotic division happens but stops in metaphase 2 (unless fertilised)

23
Q

What organelles are found in the oocyte cytoplasm?

A

There are mitochondria dispersed through the cyto

There are endoplasmic reticulum accumulated in the oocyte cortex which create cortical granules (in an immature oocyte these are dispersed by in a mature oocyte they go to the margins)

24
Q

How long do sperm survive in the female genital tract?

How long does the oocyte survive?

A

Sperm can survive for up to 5 days

Oocyte is survives 6-24 hours before phagocytosis

25
Q

How long does it take the oocyte to travel from the ovary to the uterus?

A

3-4 days

26
Q

What layers does the sperm need to penetrate before it can fertilise the oocyte ?

A

The corona radiata (the follicular cells) and the zona pellucida (the glycoprotein membrane)

27
Q

Describe the capacitation of sperm

A

The sperm cell membrane has to change to allow fusion with the oocyte

  • the protein coat is removed
  • The acrosomal enzymes are exposed
  • the tail movements changes from beat to whipping action
28
Q

What is the acrosome reaction that occurs in sperm?

A

When the sperm contacts the corona radiata it has intact acrosome - the sperm pushes through this layer and proteins on the sperm bind to the ZP3 proteins of the zona pellucida.

This binding triggers a reaction:

  • acrosomal enzymes digest through the zona pellucid
  • one sperm fuses with oocyte
  • there is a cortical reaction (involving cortical granules in oocyte) to prevent polyspermy
29
Q

What are the 2 major regions of the oocyte plasma membrane?

Which one does the sperm bind to?

A

Smooth surface devoid of microvilli: the part of the membrane that directly overlie the metaphase chromosomes

Surface rich in microvilli: the remainder, this is where the sperm fuses

30
Q

Outline the fast block and slow block of polyspermy

A

Fast block: sodium channels open which causes a wave of depolarisation across the oocyte membrane , preventing further fertilisation

Slow block: the cortical granules release enzymes to stimulate adjacent granules to undergo exocytosis.

31
Q

What is syngamy?

A

The union of male and female pronuclei to form a diploid zygote

32
Q

What is polyploidy?

What are the causes

A

A embryo containing 3 or more pronuclei are polyploidy

Caused by entry of more than one sperm or failure of a second polar body to be extruded

33
Q

How are monozygotic and dizygotic twins produced?

A

Monozygotic twins - in cleavage the totipotent cells divide into 2 separate masses

Dizygotic twins - 2 eggs ovulate and are both fertilised

34
Q

What is compaction?

A

At the 8 cell stage blastomeres undergo polarisation to form tight junctions to create an inner embryo environemnt

35
Q

What is a morula?

A

The 16 cell blastomere stage - looks like a raspberry

Occurs 3-4 days after fertilisation and passes into the uterus

36
Q

What is the role of the trophoblast?

A

It contributes to formation of the placenta and produces hCG

37
Q

Outline the process of hatching

A

There is digestion of a section of zona pellucida by an enzyme produced in trophoblast cells

Th hatching occurs of the side opposite the inner cells mass to minimise risk of enzymatic damage to the embryo

The blastocyst can then implant