Repro Flashcards
Pt had D&C, has not had menses since, what should be high on differential?
Asherman syndrome
- scraped off stratum basalis, leaving endometrium inadequate for implantation (too much scar tissue/adhesions)
deficiency in mineralocorticoids (aldosterone)
- hyponatremia, hyperkalemia, HYPOtension
- ambiguous genitalia d/t overproduction of androgens
21-b-hydroxylase deficiency (MCC CAH)
- hypotension activates RAAS
overproduction of mineralocorticoids with decreased levels of glucocorticoids and gonadal steroids
- HTN, hypokalemia
17-a-hydroxylase def
placenta adheres to surface of the myometrium, rather than decidua of uterus
placenta accreta
chorionic villi penetrate through the myometrium, to the uterine serosa or adjacent organs
placenta percreta
chorionic vili penetrate into myometrium
placenta increta
lutenized follicle cysts within the ovary
- woman presenting with unilateral or bilateral cystic adnexal masses with a history of recent pregnancy, known gestational trophoblastic disease, multiple gestations, ovarian hyperstimulation, or a pregnancy complicated by fetal hydrops
theca lutein cyst
- form as a result of overstimulation from high levels of hCG
- ovarian fibroma (proliferating spindle-shaped fibroblasts)
- ascites
- pleural effusion
Meigs syndrome
- removal of the fibroma results in elimination of ascites and pleural effusion
women in 30-40’s, pelvic pressure, pain, menorrhagia, and dysmenorrhea
- MC tumor in females
- appear as calcified lesions on xray
leiomyoma
- benign neoplasm of smooth muscle
- can cause spontaneous abortion and infertility
persistent scaling, eczematous eruption, or ulcerating lesion involving the nipple and areolar complex
- nipple may appear scaly or crusted, raw, vesicular, or ulcerated
Paget disease of breast
Paget disease of breast is a risk factor for what malignancy?
invasive ductal carcinoma
rapid onset and presents as red, warm, edematous skin that resembles inflammation
- thickening and dimpling of the skin that resembles an orange peel (peau d’orange)
inflammatory breast carcinoma
bloody nipple discharge without a palpable mass
intraductal papilloma
do aldosterone levels increase or decrease in pregnancy?
increase
does GFR increase or decrease in pregnancy?
increase
does systemic vascular resistance increase or decrease in pregnancy?
decrease
does tidal volume increase or decrease in pregnancy?
increase
does expiratory reserve volume increase or decrease in pregnancy?
decrease
does thyroid binding globulin increase or decrease in pregnancy?
increase
- bound T3/T4 increases
- free thyroxine (T4) remains the same
rare ovarian tumor containing ectopic thyroid tissue as the major cellular component
- nonspecific presenting symptoms that may include a pelvic mass, abdominal pain, ascites, abnormal vaginal bleeding, and hyperthyroidism
struma ovarii
what is the most common hormonal elevation seen in PCOS?
increase in LH (LH:FSH > 2)
- increase in LH occurs due to pituitary oversecretion and leads to both decreased synthesis of FSH as well as increased androgen production
what produces b-hCG?
syncytiotrophoblast of placenta
- also produces progesterone and human placental lactogen (aka human chorionic somatomammotropin) during pregnancy
what adverse effect can metoclopramide have on breast tissue?
it is an anti-dopaminergic -> stops inhibition of prolactin -> galactorrhea
male, 15-35 with a firm, nontender testicular mass that does not transilluminate
- precocious puberty, gynecomastia, impotence, or loss of libido
choriocarcinoma
solid, lobulated, yellow-tan tumor
- men of all ages, present with virilization and gynecomastia
- round nuclei, single prominent nucleoli, and abundant eosinophilic cytoplasm or abundant clear cytoplasm
- reinke crystals (rod-shaped intracytoplasmic crystal-like inclusions with rounded ends)
- inhibin alpha is tumor marker
leydig cell tumor
occur both in children and in middle-aged adults
- well-circumscribed and pale yellow to whitish gray in color
- uniform tall polyhedral cells that are arranged in nests, sheets, and cords resembling spermatic tubules
- perinuclear aggregates of intermediate filaments
- inhibin alpha is tumor marker
sertoli cell tumor
most common testicular neoplasm in infants and children
- painless and bulky testicular mass
- honeycomb pattern
- *schiller duval bodies (central vessel lined by fibrous tissue and surrounded by malignancy epithelial cells in a cystic space)
- a-fetoprotein is tumor marker
yolk sac tumor
cystic swelling of the chorionic villi and proliferation of trophoblastic tissue, without formation of any fetal tissue or amniotic fluid
- abdominal growth, hCG much higher than normal pregnancy ( >200,000)
complete mole
- partial mole will not have as high hCG
what is the dominant estrogen of late pregnancy?
estrone
- estradiol is dominant estrogen every other time
X-linked dominant, mutation causes methylation of FMR1 gene
- leads to CGG trinucleotide repeat
- mental retardation and autistic-like behaviors
fragile X
hyperphagia, early-onset obesity, hypogonadism, developmental delay, and hypotonia
- small hands and feet, almond shaped eyes
- paternal deletion on Xsome 15, mom’s copy is imprinted
Prader-Wili
lack of embryonic migration of the olfactory bulb cells to the hypothalamus
- lack of puberty development
- lack of secondary sex characteristics
- decreased GnRH, LH, and FSH
- decreased sense of smell
Kallman syndrome
- idiopathic hypogonadotropic hypogonadism that results from a deficiency of a gonadotropin-releasing hormone (GnRH) from the hypothalamus
pain caused by the abnormal implantation of endometrial glandular and stromal tissue within the myometrium
- uniformly enlarged and boggy uterus on physical examination, can be tender
adenomyosis
- more common in multiparous women, women over the age of 35, and those with a history of uterine surgeries such as cesarean section
pale, ovoid nucleus, large nucleolus, and a large amount of pale-staining cytoplasm
- what are they called and when would you see them?
halo cells
- Paget dz of breast
benign, small tumor that is found beneath the areola
- typically presents as bloody nipple discharge in woman less than 50
intraductal papilloma
multiple bilateral malignant breast lesions
- histo shows orderly row of cells, often described as “Indian files.”
invasive ductal carcinoma
bilateral ovarian metastases from a gastrointestinal tract adenocarcinoma
- invasive, mucin-filled, signet ring cancer cells
- associated with acanthosis nigricans and leser-trelat sign
Krukenberg tumor
what dopamine agonist is used to treat galactorrhea by inhibiting prolactin?
bromocriptine
- short stature, web necked, widely spaced nipples
- streak ovaries (ovarian dysgenesis)
- infertility d/t primary amenorrhea (low estrogen) -> high LH/FSH
- horseshoe kidney and bicuspid aorta
turner syndrome
male with gynecomastia, erectile dysfunction and decreased libido
- potential galactorrhea
prolactinoma
- pituitary adenoma that secretes excess prolactin, which decreases the secretion of GNrH and therefore, lowers LH and FSH
hyperandrogenism, irregular menstrual cycles
- increased LH and total testosterone, decreased FSH
- state of hyperinsulinemia and insulin resistance
PCOS
LH activates what enzyme in theca cells?
desmolase
- produces androstenedione
FSH activates what enzyme in granulosa cells?
aromatase
- produces estrogen
where is oxytocin produces?
hypothalamus
- released from posterior pituitary (same as ADH)
taking tamoxifen (SERM) after mastectomy increase your chance of what?
endometrial carcinoma
tx for endometriosis
- synthetic androgenic steroid that inhibits pituitary secretion of FSH and LH, inhibiting ovulation and ovarian estrogen release
danazol
MCC primary amenorrhea
- short stature, horseshoe kidney, coarctation of aorta, Madelung deformity of wrist, conductive hearing loss
Turner syndrome
what ligament is almost always involved in ovarian torsion?
infundibulopelvic (suspensory ligament of ovary)