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Biología molecular > REPARACIÓN DEL ADN > Flashcards

REPARACIÓN DEL ADN Flashcards

1
Q

Tendencia a presentar mutaciones en el ADN

A

INESTABILIDAD DEL ADN

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2
Q

MECANISMO DE DAÑO AL ADN

A

-ENDÓGENOS
-EXÓGENOS

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3
Q

TLS

A

POLIMERASAS DE SÍNTESIS A TRAVÉS DE LESIÓN

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4
Q

¿Qué sucede si el daño persiste?

A

APOPTOSIS

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5
Q

TIPOS DE DAÑO DEL DNA:
ENDÓGENOS

A

-Error replicativo

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6
Q

ERROR REPLICATIVO
¿Cuándo sucede?

A

REPLICACIÓN

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6
Q

ERROR REPLICATIVO

A

DNA polimerasas incorporan el nucleótido erróneo, generando mutuaciones espontaneas.

TOPOISOMERASA: mal alineamiento de las hebras (al momento de cortar y volver a pegar se pueden equivocar), También hay un exceso en las topoisomerasas.

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7
Q

ENZIMAS que ayudan a la corección de las topoisomerasas en el error replicativo

A

Tirosil DNA fosfodiesterasa
Endonucleasas

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8
Q

Desaminar se refiere a

A

Quitar grupo amino

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9
Q
A
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Biología molecular (6 decks)

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