Repair

Question 1

Resolution

Answer 1

rapid healing

epithelial cells regenerate by increaing mitosis

Question 2

Labile Cells

Answer 2

Constant turnover by mitosis

Question 3

Regeneration

Answer 3

Growth factor released
increased mitosis
paranchymal cells

Question 4

paranchymal

Answer 4

same function

little evidence of injury

Question 5

stable cells

Answer 5

can resume regeneration if conditions are right

require a supportive framework

Question 6

Replacement/connective tissue repair

Answer 6

inflammatory phase
proliferative phase
remodelling phase

lost tissue is replaced by granulation tissue matures to scar tissue

Question 7

inflammatory stage

Answer 7

first 6-8hours
vascular response
cellular response
phagocytosis
lymphatic drainage

Question 8

proliferative phase

Answer 8

24-48 hours
fibroblast macrophages and blood vessels proliferare to form granulation tissue
angiogenesis- leaky capilarries WBC and plama proteins leak into tissue
fibroblast secrete collagen (type III)

Question 9

Re-modelling phase

Answer 9

3/52 to 2 yrs
Fibroblast synthesise Collagen (type I)
lysis of type III collagen by collagenase enzymes
continual remodelling of scar tissue in relation to physical stress

Question 10

factors that affect wound healing

Answer 10

malnutrition
blood flow
oxygen delivery
infection
wound separation
foreign bodies
age
adhesion
drying of wound
nature and site of injury
sinus and fistula formation
temperature 
drugs
excessive movement
prolonged inflammation

Question 11

Complications

Answer 11

infection
ulceration- open lessions
dehiscence- separation of wound
Keloid development- excessive cellulose
adhesion- fibres between cavities and tissues