reoviridae Flashcards
reoviridae
REO-> respiratory enteric orphan
reoviridae general
nonenveloped, spherical, ds RNA segments 10-12 depending on genus, replication in cytoplasm
segments allow for genetic reassortment
subfamilies of reoviridae
sedoreovirinae and spinareovirinae
sedoreovirinae important genera
orbivirus-african horse sickness, blue tongue virus
rotavirus-RVA
spinareovirinae important genera
orthoreovirus-avian reovirus
coltivirus-colorodo tick fever virus
blue tongue
most susceptible host-sheep, fine wool in europe and white-tailed deer. Inapparent infection in cattle which are primary reservoir and amplifying host
Blue tongue (BTV)
List A disease, part of orbivirus
10 segments dsRNA genome
BTV transmission
transmitted biologically by certain species of culicoides sonorensis
can be venereal or trans placental transmission
BTV path
vascular endothelium damage, intravascular coagulation, necrosis of tissues and organs, edema, hemorrhage, congestion, abortion, CNS malformations
BTV clinical findings
profuse salivation, edema of muzzle, reddening of nasal mucosae, mucopurulent nasal discharge, often blood stained, crust formation on nostrils and lips
cyanosis on the tongue, necrotic ulceration, erosion of dental pad, necrosis, hyperemia, ulceration in oral cavity, coronitis and laminitis
Dx of BTV
immunohistochemical tests such as immunoflourescence and immunoperoxidase test, PCR, ELISA
african horse sickness (AHS)
infectious, noncontagious, arthropod bourne disease of horses, donkeys and mules, sometimes dogs List A disease enzootic to sub saharan africa
AHS etiology
orbivirus, nine serotypes based on capsid protein VP2 and VP5 variation
AHS transmission
cullicoides regularly in most countries of subsaharan africa
AHS clinical findings
profuse nasal discharge od serous and froth that may be blood stained, pulmonary edema, interlobular edema of lungs, hydroperitoneum, hydropericardium, edema of muscles, edema of eyelids
AHS prevention and control
vaccination in enzootic areas, control of vector, reduced exposure to biting insects, slaughter of sick or viremic
rotavirus
major cause of sever viral diarrhea in young animals and birds, 11 segments of dsRNA, VP6 protein variations, RVAs cause the diarrhea
RVA strain Wa: G1P1A(8)
G1= is G genotype/serotype
P1A(8): 1 A is P serotype
(8) is Pgenotype
rotavirus transmission in animals and humans
infected stool has large number of visions, fecal oral transmission, virus replicates in mature enterocytes on the villi of upper small intestine
rotavirus pathogenesis
after ingestion can either infect intestinal villus cells damaged during virus replication and release or NSP4 acts as an enterotoxin
rotavirus symptoms
severe diarrhea in young of different animals, profuse diarrhea, anorexia, dehydration and occasionally mild fever, feces are watery to pasty pale yellow sometimes filled with mucous and blood flecks
rotavirus Dx
PAGE gel
avian reovirus
viral arthritis/tenosynovitis
broilers, turkeys, transmission fecal oral, arthritis common in the hock joint
avian reovirus clinical findings
lameness, tensosynovitis, swollen and inflamed hock joints, clear synovial fluid and inflammation of synovial membranes, ruptured gastrocnemius tendons
avian arthritic prevention
live and killed vaccines available, passive immunity to chicks
