Renin release

Question 1

What 3 factors trigger release of renin?

Answer 1

1) sympathetic stimulation
2) renal hypoperfusion
3) decreased sodium delivery to distal tubule (macula densa)

Question 2

What are 3 factors that cause renal hypo-perfusion?

Answer 2

a) decreased circulating volume
b) low cardiac output (usually high volume state)
c) renal artery stenosis

Question 3

What is the effect of diuretics on renin?

Answer 3

increase renin release - “because of decreased renal blood flow”……

Question 4

What is the effect of clonidine on renin release?

Answer 4

inhibits it because less sympathetic stimulation of B1 receptors on juxtoglomerular cells

Question 5

What is the effect of arteriolar vasodilators on renin release?

Answer 5

slightly increased because arteriolar dilation reduced total peripheral resistance which causes slight hypoperfusion of kidneys….

Question 6

ACE inhibtors and ATII receptor blockers do what do renin release?

Answer 6

slight increase due to vasodilation and slight renal hypopersion