Renal System Pharmacology

Question 1

Loop diuretics also prevents reabsorption of other ions like…….

Answer 1

HCO3 HPO4 and H+

Question 2

The bioavailability of ethacrynic bumetanide, torsemide and furosemide are ………,……… and ………… respectively

Answer 2

100% ,80%, 80%, 60%

Question 3

The half life of LDs are ……….

Answer 3

1-4hours

Question 4

Thiazide results in hypercalcemia by …………………

Answer 4

Stimulating parathamone which increases the reabsorption of ca

Question 5

The first CAI inhibitor to be introduced are

Answer 5

Sulphanilamide

Question 6

The half-lifes of acetazolamide and methazolamide are ………….. and ……….. respectively

Answer 6

7hrs
14hrs

Question 7

Acetazolamide is excreted unchanged in the urine while …………. % methazolamide are with ……….% metabolised through unclear means

Answer 7

25 % unchanged
75% metabolized

Question 8

Furosemide is competitively inhibited by……….

Answer 8

Probenecid

Question 9

Furosemide is excreted unchanged T/F

Answer 9

True

Question 10

Why are loop diuretics not used in the treatment of hypertension

Answer 10

Due to their short half life

Question 11

The thiazide which still retains a significant CAI property is

Answer 11

Chlorthalidone

Question 12

The only thiazide available for parenteral route is…….

Answer 12

Chlorothiazide

Question 13

List the three thiazide that are in clinical use in nigeria

Answer 13

Indapamide
Chlorthalidone
Hydrochlorothiazide( prototype)

Question 14

List the osmotic agents used as diuretics

Question 15

Eplerenone is metabolised by CYP3A4
And can be inhibited by……..

Answer 15

Erythromycin
Dilitiazem
Fluconazole
Grapefruit

Does not affect spironolactone