Renal Review - Associations by words Flashcards
If you see…
Think:
NSAIDS
minimal change GN in kids
p-ANCA
Churg Strauss and Microscopic polyangiitis
c-ANCA
Granulomatous polyangiitis
Alpha-5 chain of Type IV collagen
X linked Alport Syndrome
Alpha-3 or 4 chain of Type IV collagen:
autosommal recessive Anti-GBM disease (good pastures)
Hep B and C infection:
Polyarteritis Nodosa, Membranous nephropathy
Fibrosis of media and disruption of EM
Polyarteritis Nodosa
Hyaline glomeruli; BM and podocytes on EM
Membranous Nephropathy
Hep C infection
Membranoproliferative GN
HIV
FSGS
Von willebrand factor protease
TTP (thrombocytopenic purpura)
FAT RN (fever, anemia, thrombocytopenia, renal and neural involvement) in 30-40yo F
TTP
SPEP, UPEP
Amyloidosis (SPEP and UPEP are serum proteins)
Thrombi and fibrinoid necrosis in capillaries and arterioles
thrombotic microangiopathy (TMA) – TTP (thrombocytopenia purport) and hemolytic uremic syndrome (HUS) are two types
Shiga-like toxin:
classic HUS (hemolytic-uremic syndrome) – bloody diarrhea + ARF (more children) if classic; no diarrhea and insidious if atypical (adults >children)
Factor H defects / Genetic defects in alternative complement pathway activation:
atypical HUS –> TMA
Anti-phospholipase A2 Receptor Ab
Membranous Nephropathy
Antiphospholipid antibody syndrome
SLE, can cause thrombotic microangiopathy
Pulmonary hemorrhage
anti-GBM disease
Hemoptysis
Wegeners and goodpasture
Dominant IgA staining on IF
IgA nephropathy
Arteriolar hyalinosis
benign nephrosclerosis
Petechial hemorrhages
malignant HTN
Onion skinning
malignant HTN, chronic transplant rejection
URT involvement
Wegeners/ Granulomatosis Polyangiitis (cANCA)
Sinus problems
Wegeners (C-Anca) and Microscopic Polyangiitis (P-ANCA)
Lung Involvement
Goodpasture, Churg Strauss, Wegeners
Digalactoside residue
ecoli fimbriae adhere to