Renal Pathology 4: Tubular Disease (Dobson) Flashcards
Two major processes that lead to AKI
- ischemic or toxic tubular injury
- inflammation of the tubules and interstitium
Acute Tubular Injury (ATI)
most common cause of AKI; damage to tubular epithelial cells and acutely diminished renal function; 50% occur in hospitalized patients reversible process; can lead to death if untreated
Ischemic ATI
due to decreased or interrupted blood flow (trauma, sepsis, shock)
Nephrotoxic ATI
may be caused by endogenous agents (gentamycin)
The two critical events of ATI
- tubular injury
- persistent and severe disturbances in blood flow
leads to decreased urine output and decreased GFR
Initiation phase of ATI
last about 36 hours, dominate by inciting medical, surgical obstetric event; ONLY indication of renal involvement is slight decline in urine output and rise in BUN
Maintenance phase of ATI
oliguric crisis; sustained decreases in urine output between 40 and 400 mL/day (oliguria), salt and water overload, rise in BUN, hyperkalemia, metabolic acidosis, and other manifestations of uremia; can overcome with tx
Recovery phase of ATI
steady increase in urine volume that may reach 3 L/day; tubules are still damaged (large amounts of water, Na+ and K+ are lost to urine) HYPOkalmeia NOT hyperkalemia becomes clinical problem
The 3 phases of ATI
- Initiation phase: 36 hrs, slight decline in urine output
- Maintenance phase: oliguric crisis; HYPERkalemia
- Recovery phase: increase in urine output; HYPOkalemia
How are tubulointerstitial disorders distinguished clinically from glomerular diseases?
- Absence of nephritic and nephrotic syndrome
- Presence of defects in tubular function, evidence of polyuria or nocturia, salt wasting; diminished ability to excrete acids (metabolic acidosis); isolated defects in tubular reabsorption and secretion
Pyelonephritis
inflammation of affecting tubules, interstitium, and renal pelvis. Two forms: acute and chronic
Acute Pyelonephritis
suppurative inflammation involving kidneys; generally caused by bacterial infection and associated with UTI
Chronic Pyelonephritis
more complex; bacterial infections play dominant role but other factors (VUR/obstruction) predispose to repeat episodes
How do the infectious organisms make it to the kidneys in Pyelonephritis?
hematogenous infection (Staphylococcus or E. coli) renal a. to kidneys OR UTI (E. coli) bacteria enters bladder, goes passed the vesicoureteral junction, then the VUR into the intrarenal reflux
Clinical presentation of pyelonephritis
CVA tenderness
Systemic features (fever, elevated WBC)
Dysuria, frequency, urgency