Renal Pathology Flashcards
List the main conditions that are associated with immunoglobulin or complement deposition. (2)
- Membranous nephropathy
2. Membrano-proliferative glomerular nephritis
List the main conditions that are associated with a hypercellular lesion (nephritic). List 5
- IgA nephropathy
- Post-infectious glomerulonephropathy
- Membranoproliferative GN
- Lupus nephritis
- Crescentic GN
List the main conditions that are associated with a normal/hypocellular lesion (nephrotic).
- Minimal Change disease
- Focal segmental sclerosis
- Membranous lesion
- Diabetic nephropathy
- Amyloidosis
When should you suspect subepithelial deposits by LM?
answer
When will you see subepithelial deposits by EM?
answer
When will you see foot process effacement by EM?
Various, espcially Minimal Change Disease
Describe the LM findings with diabetic nephropathy.
answer
When will you see dysmorphic RBCs and RBC casts?
answer
List the two categories and 8 diseases of Acute Kidney Injury.
Tubulointerstitial disease
- Acute tubular necrosis
- Acute interstitial nephritits
- Myeloma cast nephropathy
Vascular Diseases
- Thrombotic microangiopathies
- Atheroembolic disease
- Malignant hypertension
- Renal infarction
- Renal vein thrombosis
List the 2 categories and 2 disease of Chronic Kidney Disease.
Tubulointerstitial diseases
- Chronic interstiital nephritis
Vascular diseases
- Hypertensive nephrosclerosis
What are the 2 main causes of Acute Tubular Necrosis (ATN)?
- Ischemia
2. Toxins
List 5 causes of ischemic injury that can precipitate Acute Tubular Necrosis (ATN).
- Septic shock
- Burns
- Hemorrhage (crush injury)
- Prolonged dehydration
- Advanced congestive heart failure
List 6 exogenous and 2 endogenous nephrotoxic injury.
Exogenous
- Antibiotics (aminoglycosides) and antivirals
- IV contrast media
- Immunosuppressive agents
- Chemotherapeutic agents
- heavy metals
- Organic solvents
Endogenous
- Hemoglobin (hemolysis)
- Myoglobin (rhabdomyolysis)
