Renal Path 1

Question 1

What are the name of the three diseases mentioned in this lecture?

Answer 1

Acute post-infection nephritis

IgA nephropathy/ Berger Disease

Hereditary nephritis: Aliport’s syndrome

Question 2

Name the disease:

*no immune complexes

*X-linked

*Aliport’s syndrome: vision (cataracts) + hearing + renal issues *hematuria

*mutation in BM proteins leading to collagen IV defect

**most common in children

Answer 2

Hereditary nephritis

Question 3

Name the disease:

*low complement levels + elevated ASO titer

*GABHS: group a & b beta hemolytic strep

*most common in young children

*histo: tubular neutrophilic infiltrate, IC deposit on IF, capillary lumen narrows

*coca cola stained urine

Answer 3

Post-infection glomerulonephritis

Question 4

Name the disease:

*RECURRENT hematuria every 1-3 months

*hematuria last for three days

*associated with mucosal infections/URIs

*mesangial proliferation + dense deposits

*mucosal antibody in excess

*most common in young adults

Answer 4

IgA nephropathy

Question 5

What are the treatments of these diseases?

Answer 5

Acute glomerulonephritis & IgA: supportive therapy to treat patients symptoms

Hereditary: transplant, genetic testing, supportive treatment

Question 6

What are some complication of these diseases?

Answer 6

Renal failure

Question 7

Which diseases have no abnormality in the amount of IC present?

Answer 7

• IgA nephropathy
• Hereditary nephritis