Renal Miscellaneous

Question 1

What characteristic of oral contraceptives can induce drug-resistant/induced 2⁰ HTN?

Answer 1

High ER

Question 2

What is an ex of a weight loss medicine that can induce drug-resistant/induced 2⁰ HTN?

Answer 2

Phentermine: psychostimulant w/ PHM similar to amphetamine (indirect sympathomimetic for narcolepsy, obesity, ADHD)

Question 3

What are 2 ex’s of stimulants that can induce drug-resistant/induced 2⁰ HTN?

Answer 3

Methylphenidate & Amphetamines (both used for ADHD)

Question 4

What are 2 ex’s of corticosteroids that can induce drug-resistant/induced 2⁰ HTN?

Answer 4

Glucocorticoids & Mineralcorticoids

Question 5

What are 2 ex’s of decongestants that can induce drug-resistant/induced 2⁰ HTN?

Answer 5

Phenylephrine & Pseudoephedrine (alpha-adrenergic agonists)

Question 6

What is an ex of a recombinant cytokine that is used to stimulate BM, esp in anemias related to renal failure, that can induce drug-resistant/induced 2⁰ HTN?

Answer 6

Erythropoietin

Question 7

What is are 2 ex’s immunosupressants that can induce drug-resistant/induced 2⁰ HTN?

Answer 7

Cyclosporine & Tacrolimus
Both are Calcineurin inhibitor; block T cell activation by preventing IL-2 transcription; both nephrotoxic

• *Cyclosporine:** binds cyclophilin
• *Tacrolimus:** binds FK506 binding protein (FKBP)

Question 8

What are 2 ex’s of atypical antipsychotics that can induce drug-resistant/induced 2⁰ HTN?

Answer 8

Clozapine & Olanzapine

Question 9

What are 2 ex’s of antidepressants that can induce drug-resistant/induced 2⁰ HTN?

Answer 9

TCA’s & SSRI’s

Question 10

What are 2 ex’s of illicit drugs that can induce drug-resistant/induced 2⁰ HTN?

Answer 10

Methamphetamines & Cocaine

Question 11

What are 2 drugs and 3 medical conditions that can form red urine?

Answer 11

Drugs: Rifampin (for Mycobacterial TB, meningococcal prophylaxis & chemoprophylaxis in contacts of children w/ H influenzae type b)
or Phenytoin (Cytochrome P40 inducer)

UTI’s, Rhabdomyolysis, Porphyria & Nephrolithiasis

Question 12

What 3 agents can cause orange urine?

Answer 12

Vit C
Rifampin and Phenazopyridine (analgesic)