Renal III Flashcards
RBC casts
glomerulonephritis
malignant HTN
muddy brown cysts
acute tubular necrosis
oval fat bodies
fatty cast
with nephrotic syndrome
waxy cast
end stage renal disease
focal
diffuse
> 50% glomeruli
nephritic syndromes
PSGN RPGN IgA nephropathy - berger alport MPGN
nephrotic syndromes
FSGS minimal change disease membranous nephropathy amyloid diabetic glomerulonephropathy
nephritic
GBM disruption
-inflammatory process
nephrotic
podocyte disruption
> 3.5 g/day
PSGN
strep pyogenes - group A strep infection
-type III hypersensitivity
starry sky - granular
lumpy bumpy IgG, IgM, C3
subepi IC deposits
resolve spontaneously
anti-DNase B titers and low complement
RPGN
crescentic
fibrin and plasma proteins (C3b)
poor prognosis
goodpasture
type II hypersensitivity
anti-GBM Abs - linear deposits
nephritic syndrome
progress - RPGN type I
granulomatosis with polyangiitis
wegener
PR3-ANCA
cANCA
can lead to RPGN
microscopic polyangiitis
MPO-ANCA
pANCA
can lead to RPGN
DPGN
with SLE or MPGN
wire looping caps
subendo and intramembrane IgG ICs
IF - granular
IgA nephropathy
berger disease
LM - mesangial proliferation
EM - mesangial IC deposits
IF - IgA IC deposits in mesangium
renal path of HSP
alport syndrome
type IV collagen
thin and split BM
most common X-linked
get eye problems, glomerulonephritis, sensorineural deafness
can’t see, can’t pee, can’t hear a buzzing bee
alport syndrome
get glomerulonephritis
retinopathy and lens dislocation
due to type IV collagen mutation
MPGN
type I - subendo deposits - tram track
-association hep B and C
type II - intramembranous - dense deposits
-association C3 nephritic factor - stabilize C3 convertase
FSGS
segmental sclerosis and hyalinosis
focal deposits IgM, C3, and C1
effacement of foot processes
in AAs and hispanics
HIV, sickle cell, heroin abuse, massive obesity, IFN tx
liphoid nephrosis
minimal change disease
effacement of foot processes - electron microscopy
normal glomeruli on light microscopy and IF
in children
excellent response to corticosteroids
membranous nephropathy
LM - diffuse cap and GBM thickening
IF - granular deposits IC
EM - spike and dome appearance - subepi deposits
poor response to steroids
may progress chronic renal disease
kimmelstein wilson nodules
nonenzymatic glycosylation of GBM
pink diffuse mesangial deposition
