Renal History

Question 1

Drug History: What antihypertensives are nephrotoxic? Mechanism of nephrotoxicity.

Answer 1

ACE inhibitors & ARBs

Both drugs inhibit Angiotensin II > Angiotensin II has a vasoconstrictive effect > Vasodilate > GFR reduced

Question 2

Drug History: What pain drugs are nephrotoxic?

Answer 2

NSAIDs and analgesics

Question 3

Drug History: How do NSAIDs reduce GFR and cause renal failure?

Answer 3

Inhibit vasodilating prostaglandins

Question 4

Drug History: What drugs can cause hypertension?

Answer 4

Antibiotics: ciclosporin
Hormones: oestrogen/prosgesterone contraceptive pill
Steroids
Erythropoietin