Clinical Exam Flashcards
What are the signs of uraemia?
Uraemic tinge/fetor
Hiccups
What to look out for in a patient with kidney problem for general appearance?
- Uraemic signs - fetor/tinge/hiccups
- Acidosis - hyperventilation
- Hypocalcemia - tetany (Chvostek/Trosseau), twitching, myoclonic jerks
- Fluid balance - signs of dehydration & fluid overload (JVP, pulmonary oedema, ascites, peripheral oedema)
What are signs of hypocalcaemia?
Calcium > muscle not working > twitching, myoclonic jerks, tetany (Chvostek sign, Trousseau sign)
As part of fluid balance check, what should you measure during exam?
The patient’s weight
How to check for fluid balance?
- AKI due to dehydration: look for signs of dehydration - dry mucous membranes, reduced skin turgor, postural hypotension
- Fluid overload: JVP, signs of pulmonary oedema, ascites, peripheral oedema
How to check for urinary incontinence?
Look for stains on bed or patient’s clothing before balloting the kidneys.
What do Muehrcke’s (mew-rook’s) nails indicate?
Nephrotic syndrome/hypoalbuminemia
What do Mee’s lines indicate?
Renal failure
What to look for in the hands after general appearance?
- Nail changes: e.g. Muehrcke’s lines (hypoalbuminemia), Mee’s lines (renal failure), half-and-half nails (CKD), capillary refill*
- Anemia - palmar crease pallor
- Asterixis - severe CKD
How do half-and-half nails look like?
Distally its red, proximally its white colour.
What cause anaemia in CKD?
- Chronic disease
2. Lack of erythropoietin prdtion
What is the difference between an AV fistula and a shunt?
AV fistula is an anastomosis between an artery and a vein (direct connection)
Whereas a shunt is an extra graft extending between the artery and vein
Why are dialysis patients more prone to carpal tunnel syndrome?
Due to AV fistula and uraemic neuropathy.
What is a sign of carpal tunnel syndrome in dialysis patients? However do patients usually present with such specific numbness? If not then what do they present with.
Numbness over the median nerve distribution - radial side 3 fingers.
Often present with numbness of the whole hand.
After examining the hands and moving up to the arms in renal patients, what should you look for?
in the arms:
- scars - signifying previous thrombosed shunts
- AV fistulas/shunts
- check for signs of CTS i.e. numbness
- Scratch marks/excoriations
- Bruising
Scratch marks and excoriations on a renal patient indicates what?
Uremic pruritis > uremia > renal failure
Why do patients with kidney dysfunction have bruising on their arms?
Nitrogen retained in the body affects platelet aggregation resulting in bruising
What are the signs of vasculitis in renal patients?
Vasculitis may present as:
- sensory or motor neuropathy e.g. weakness, diminished sensation
- palpable purpura
What additional exams would you like to do to complete the renal exam?
- Neurological exam: specifically for peripheral neuropathy (sensation, reflexes)
2.
What does rash indicate as the cause of renal disease?
SLE and systemic sclerosis
After examining the arm and moving to face, what signs to look out for in the renal patient?
- Rash: indicate SLE, systemic sclerosis
- Conjunctival pallor (indicative of anaemia)
- Eyes: band keratopathy (hyperparathyroidism), conjunctival pallor
- Mouth: gingival hyperplasia (calcineurin inhibitors), uremic fetor
What is band keratopathy and how is it related to renal disease?
Band keratopathy is a white smudge across the eyes (caused by calcium deposition). Get this because of secondary/tertiary hyperparathyroidism. Secondary hyperparathyroidism is caused by hypocalcemia of renal disease and low vitamin D levels.
Why do patients with CRF get hyperphosphatemia, hypocalcemia, and secondary hyperparathyroidism.
Because impaired kidneys cannot properly excrete phosphate, calcium phosphate forms binding to all the calcium and decreasing serum calcium. Parathyroid hormone secretion increases to correct the hypocalcemia.
What do normal kidneys do to Vitamin D? How does this relate to hyperparathyroidism and its sign on clinical examination?
Normal kidneys convert vitamin D into its active form. With impaired renal function, active vitamin D levels decrease, stimulating parathyroid secretion. Patient may have band keratopathy (calcium deposition in eyes) as a result of parathyroid hormone increasing calcium absorption.
While inspecting the face, what do you want to look for in the mouth that can suggest that this is a post-transplant patient on a particular class of drugs?
Gingival hyperplasia is the result of taking calcineurin inhibitors (e.g. tacrolimus and cyclosporin), which are immunosuppressant drugs used for post-renal transplant.