Renal Function

Question 1

what is a normal creatinine clearance for adults?

Answer 1

120 mL/min, decreases with age

Question 2

what is the formula for creatinine clearance?

Answer 2

urine creatinine (mg/dL) x urine volume in mL/min( use volume of 24 hour collection, just convert to mins), all divided by plasma creatinine in mg/dL, and times avg BSA 1.73/pt’s BSA

Question 3

how is creatinine clearance corrected for body/kidney mass?

Answer 3

multiply the formula by 1.73/ pt’s BSA

Question 4

what are some alternatives to creatinine clearance for estimating the GFR?

Answer 4

eGFR ( a calculation), cystatin clearance, and B2-microglobulin

Question 5

what is the estimated GFR calculation based upon?

Answer 5

patient age, sex, gender, and ethnicity and SERUM CREATININE

Question 6

in whom is the eGFR esp helpful for detecting CKD??

Answer 6

those at high risk such as diabetics, pts w/ HTN, cardio disease, or family history of kidney disease