Renal Function

Question 1

5 components of renal function

Answer 1

filtration
secretion
reabsorption
endocrine function
metabolic function

Question 2

How does insulin metabolism relate to renal function

Answer 2

Decreased insulin metabolism occurs in renal failure
alterations in insulin requirements as renal failure progresses
*hypoglycemia can be the result in patients taking insulin or oral hypoglycemic agents because you’re not peeing out as much of the drug (so it stays in your body longer and acts on the glucose)

Question 3

What is the (pseudo) endocrine function of the kidneys

Answer 3

Renin secretion-juxtaglomerular apparatus is a powerful regulator of BP plays a role in many types of HTN
EPO secretion
Metabolism of prostaglandins and kinins

Question 4

Prostaglandin effect

Answer 4

They have a vasodilating effect on the renal vasculatre

NSAIDs can inhibit this effect and cause renal failure

Question 5

Definition of nephrotic syndrome

Answer 5

A nonspecific kidney disorder characterized by proteinuria

Question 6

*What does it mean if your Creatinine doubles

Answer 6

You have lost half of your kidney function

Question 7

As body mass ______ the amount of Creatinine ______

Answer 7

increases and increases

Arnold Schwarzennager has a high Cr

Question 8

Stages of renal disease

Answer 8

Based on CrCl
Stage 1: nothing wrong; GFR >90ml/min
Stage 2:  mild; GFR >60ml/min
Stage 3 (where most people are): GFR >30
Stage 4: Severe; GFR 15-29ml/min
Stage 5: need dialysis; <15 ml/min